On the relationship between incorporation of 32P into phospholipids and binding of beta-adrenoceptor blocking drugs to isolated mast cells
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
PubMed
2899380
DOI
10.1007/bf02142524
Knihovny.cz E-zdroje
- MeSH
- beta blokátory metabolismus farmakologie MeSH
- fosfolipidy metabolismus MeSH
- inbrední kmeny potkanů MeSH
- krysa rodu Rattus MeSH
- mastocyty účinky léků metabolismus MeSH
- radioizotopy fosforu MeSH
- techniky in vitro MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- beta blokátory MeSH
- fosfolipidy MeSH
- radioizotopy fosforu MeSH
The lipophilic beta-adrenoceptor blocking drugs exaprolol and propranolol significantly decreased the incorporation of 32P into phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol of isolated rat mast cells. In contrast, the hydrophilic drugs metipranolol, practolol and atenolol increased the incorporation of 32P into phosphatidylethanolamine, phosphatidylserine and phosphatidylinositol. The inhibition of 32P incorporation by lipophilic drugs correlated with the high binding of these drugs to mast cells.
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Atenolol, exaprolol and mast cell membranes
Histamine liberation as a result of nonreceptor interaction
Membrane perturbing activity of beta-adrenoceptor blocking drugs in isolated rat mast cells
