On the relationship between incorporation of 32P into phospholipids and binding of beta-adrenoceptor blocking drugs to isolated mast cells
Language English Country Switzerland Media print
Document type Journal Article
PubMed
2899380
DOI
10.1007/bf02142524
Knihovny.cz E-resources
- MeSH
- Adrenergic beta-Antagonists metabolism pharmacology MeSH
- Phospholipids metabolism MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Mast Cells drug effects metabolism MeSH
- Phosphorus Radioisotopes MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adrenergic beta-Antagonists MeSH
- Phospholipids MeSH
- Phosphorus Radioisotopes MeSH
The lipophilic beta-adrenoceptor blocking drugs exaprolol and propranolol significantly decreased the incorporation of 32P into phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol of isolated rat mast cells. In contrast, the hydrophilic drugs metipranolol, practolol and atenolol increased the incorporation of 32P into phosphatidylethanolamine, phosphatidylserine and phosphatidylinositol. The inhibition of 32P incorporation by lipophilic drugs correlated with the high binding of these drugs to mast cells.
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Atenolol, exaprolol and mast cell membranes
Histamine liberation as a result of nonreceptor interaction
Membrane perturbing activity of beta-adrenoceptor blocking drugs in isolated rat mast cells
