The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells
Language English Country Slovakia Media print
Document type Journal Article
PubMed
2342627
Knihovny.cz E-resources
- MeSH
- Adenine analogs & derivatives pharmacology MeSH
- Antiviral Agents pharmacology MeSH
- Cell Division drug effects MeSH
- DNA biosynthesis MeSH
- Leukemia L1210 pathology MeSH
- Mice, Inbred DBA MeSH
- Mice MeSH
- Tumor Cells, Cultured drug effects MeSH
- Organophosphonates * MeSH
- Organophosphorus Compounds pharmacology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- 9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine MeSH Browser
- adefovir MeSH Browser
- Adenine MeSH
- Antiviral Agents MeSH
- DNA MeSH
- Organophosphonates * MeSH
- Organophosphorus Compounds MeSH
The growth and DNA synthesis of mouse leukemic cells L1210 in vitro was inhibited by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) by 50% at concentrations of 57.0 and 185.0 mumols/l, respectively, 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) inhibited the cell growth and DNA synthesis at concentrations of 15.5 and 250.0 mumols/l. The 2-amino congeners of the above analogs were still more efficient: The corresponding values for 2-amino-PMEA were 6.0 and 10.0 mumols/l, and for 2-amino-HPMPA 19.5 and 50.0 mumols/l, respectively. The results suggest that probably at least a part of the growth inhibitory action of PMEA is due to mechanisms not related to its interference with the DNA synthesis.
