The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články
PubMed
2342627
Knihovny.cz E-zdroje
- MeSH
- adenin analogy a deriváty farmakologie MeSH
- antivirové látky farmakologie MeSH
- buněčné dělení účinky léků MeSH
- DNA biosyntéza MeSH
- leukemie L1210 patologie MeSH
- myši inbrední DBA MeSH
- myši MeSH
- nádorové buňky kultivované účinky léků MeSH
- organofosfonáty * MeSH
- organofosforové sloučeniny farmakologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine MeSH Prohlížeč
- adefovir MeSH Prohlížeč
- adenin MeSH
- antivirové látky MeSH
- DNA MeSH
- organofosfonáty * MeSH
- organofosforové sloučeniny MeSH
The growth and DNA synthesis of mouse leukemic cells L1210 in vitro was inhibited by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) by 50% at concentrations of 57.0 and 185.0 mumols/l, respectively, 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) inhibited the cell growth and DNA synthesis at concentrations of 15.5 and 250.0 mumols/l. The 2-amino congeners of the above analogs were still more efficient: The corresponding values for 2-amino-PMEA were 6.0 and 10.0 mumols/l, and for 2-amino-HPMPA 19.5 and 50.0 mumols/l, respectively. The results suggest that probably at least a part of the growth inhibitory action of PMEA is due to mechanisms not related to its interference with the DNA synthesis.
