Immune response of the long-tailed field mouse (Apodemus sylvaticus) to tick-borne encephalitis virus infection
Jazyk angličtina Země Česko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
1725516
Knihovny.cz E-zdroje
- MeSH
- buněčná imunita MeSH
- buňky NK imunologie MeSH
- interferony krev MeSH
- klíšťová encefalitida imunologie veterinární MeSH
- kultivované buňky MeSH
- makrofágy mikrobiologie MeSH
- mozek mikrobiologie MeSH
- Muridae imunologie MeSH
- myši MeSH
- náchylnost k nemoci MeSH
- nemoci hlodavců imunologie MeSH
- protilátky virové krev MeSH
- replikace viru MeSH
- slezina mikrobiologie MeSH
- viremie imunologie veterinární MeSH
- viry klíšťové encefalitidy imunologie fyziologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- interferony MeSH
- protilátky virové MeSH
The immune response following infection with a virulent strain of Central European encephalitis (CEE) virus in a natural host, long-tailed field mouse (Apodemus sylvaticus L.) and white laboratory-bread ICR mouse, was compared. Viraemia was demonstrated in ICR mice after intraperitoneal infection with a dose of 10(5) LD50/0.5 ml. The virus titres were high in the spleen and, particularly, in the brain. In A. sylvaticus the virus was detected in the blood and spleen, but not in the brain. CEE virus multiplied in peritoneal macrophages from ICR mice, but not from A. sylvaticus. The infection induced a strong interferon response in both hosts. The natural killer (NK) cell activity increase was twice as high in A. sylvaticus compared to ICR mice. The neutralization antibodies appeared sooner in A. sylvaticus and reached higher titres in the early phases of infection.
History of Arbovirus Research in the Czech Republic
