Alkyl substituent in place of the thymine methyl group controls the A-X conformational bimorphism in poly(dA-dT)
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články
- MeSH
- alkylace MeSH
- cesium MeSH
- DNA chemie MeSH
- ethanol MeSH
- konformace nukleové kyseliny * MeSH
- poly dA-dT chemická syntéza chemie MeSH
- polydeoxyribonukleotidy chemie MeSH
- roztoky MeSH
- trifluorethanol MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cesium MeSH
- DNA MeSH
- ethanol MeSH
- poly dA-dT MeSH
- poly(d(A-U)) MeSH Prohlížeč
- polydeoxyribonukleotidy MeSH
- roztoky MeSH
- trifluorethanol MeSH
Circular dichroism studies of a family of poly(dA-y5dU) polynucleotides (y = H, methyl, ethyl, propyl, butyl or pentyl) were conducted in water-alcohol solutions containing sodium or cesium counterions. The polynucleotides denatured or adopted A- or X-DNA double helices depending on the concentration and type of alcohol, type of counterions and the length of the aliphatic substituent in place of the thymine methyl group. Short aliphatic substituents and sodium cations favored A-DNA while long aliphatic substituents and cesium cations promoted X-DNA. This study demonstrates delicacy of the conformational equilibrium of poly(dA-dT) between the A- and X-DNA double helices which depends on both intramolecular and intermolecular factors.
Citace poskytuje Crossref.org
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