Indirect transfer of resistance to imipenem in a strain of Pseudomonas aeruginosa
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články
- MeSH
- antibiotická rezistence genetika MeSH
- cefazolin farmakologie MeSH
- cefotaxim farmakologie MeSH
- fenotyp MeSH
- imipenem farmakologie MeSH
- konjugace genetická genetika MeSH
- Pseudomonas aeruginosa účinky léků genetika fyziologie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cefazolin MeSH
- cefotaxim MeSH
- imipenem MeSH
Determinants of resistance of imipenem can be, in Pseudomonas aeruginosa strains resistant to this drug, transferred by transduction with wild-type phages as well as mobilized for conjugal transfer, as demonstrated by the indirect selection procedure. Exconjugants obtained in the latter type of experiments do not transfer imipenem resistance determinant to further recipient strains(s) by conjugation. Mobilized imipenem resistance is of non-hydrolytic character and its biochemical mechanism is unknown at present.
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