L-lysine production by S-2-aminoethyl-L-cysteine-resistant mutants of Arthrobacter globiformis
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
1841850
DOI
10.1007/bf02935823
Knihovny.cz E-zdroje
- MeSH
- antibiotická rezistence genetika MeSH
- Arthrobacter účinky léků genetika metabolismus MeSH
- biotin farmakologie MeSH
- cystein analogy a deriváty farmakologie MeSH
- druhová specificita MeSH
- dusík metabolismus MeSH
- glukosa metabolismus MeSH
- kultivační média MeSH
- lysin biosyntéza MeSH
- methylnitronitrosoguanidin MeSH
- mutace MeSH
- mutageneze MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biotin MeSH
- cystein MeSH
- dusík MeSH
- glukosa MeSH
- kultivační média MeSH
- lysin MeSH
- methylnitronitrosoguanidin MeSH
- S-2-aminoethyl cysteine MeSH Prohlížeč
Using mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine, a number of homoserine auxotrophs have been isolated from a glutamate-producing Arthrobacter globiformis excreting L-lysine in good amounts. For further improvement, mutants resistant to the lysine analog S-(2-aminoethyl)-L-cysteine have been isolated from homoserine auxotrophs. For the three potent mutants tested, White's medium was found to be the best. Glucose, ammonium nitrate and biotin were found to be optimum at 280 mmol/L, 40 mmol/L and 22 nmol/L, respectively. With optimal glucose, ammonium nitrate and biotin, the strain AECrVI yielded 36 g lysine per L in flask culture.
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