Relationship between gliadin peptide structure and their effect on the fetal chick duodenum
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články
PubMed
2014713
DOI
10.1007/bf01202623
Knihovny.cz E-zdroje
- MeSH
- celiakie etiologie MeSH
- duodenum účinky léků embryologie MeSH
- gliadin chemie toxicita MeSH
- kuřecí embryo MeSH
- molekulární sekvence - údaje MeSH
- sekvence aminokyselin MeSH
- zvířata MeSH
- Check Tag
- kuřecí embryo MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- gliadin MeSH
The tendency to form a beta-turn in alpha-gliadin was estimated using the B-cell determinant prediction program based on the Chou and Fasman probability of beta-turn formation. Six sequences possessing a high probability of beta-turn formation were found. A statistically high agreement was found between these six sequences and three areas in alpha-gliadin with the occurrence of Pro-Ser-Gln-Gln sequence which has recently been considered responsible for toxicity in coeliac disease. By means of solid-phase synthesis seven peptides were obtained covering the above-mentioned regions. Their toxicity was tested using the fetal chick duodenum. The results support the suggestion that peptides containing the sequences Pro-Ser-Gln-Gln and Gln-Gln-Gln-Pro may be involved in the pathogenesis of coeliac disease.
Citace poskytuje Crossref.org
