Dynamika protilátkové odpovĕdi a p 24 antigenémie u HIV-1 infikovaných osob v CSR
[Dynamics of the antibody response and p24 antigenemia in HIV-1 infected individuals in Czechoslovakia]
Jazyk čeština Země Česko Médium print
Typ dokumentu anglický abstrakt, časopisecké články
PubMed
2142624
- MeSH
- AIDS imunologie MeSH
- dospělí MeSH
- genové produkty gag - virus lidské imunodeficience MeSH
- genové produkty gag analýza MeSH
- HIV antigeny analýza MeSH
- HIV korový protein p24 MeSH
- HIV protilátky analýza MeSH
- HIV-1 imunologie MeSH
- komplex příbuzný AIDS imunologie MeSH
- lidé MeSH
- peptidy analýza MeSH
- proteiny virového jádra analýza MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- genové produkty gag - virus lidské imunodeficience MeSH
- genové produkty gag MeSH
- HGP-30 peptide, Human immunodeficiency virus-1 MeSH Prohlížeč
- HIV antigeny MeSH
- HIV korový protein p24 MeSH
- HIV protilátky MeSH
- peptidy MeSH
- proteiny virového jádra MeSH
In a group of 83 anti HIV-1 positive subjects the antibody response against different structural viral proteins was investigated concurrently with assessment of p 24 antigenaemia. Disappearance of antibodies against the capsidal antigen p 24 was recorded in 12% of 42 patients with ARC and AIDS. On the other hand, these antibodies persisted in all 41 asymptomatic infections throughout the three-year investigation period. Disappearance of antibodies against p 17 antigen was proved in 41% of the patients and in 22 subjects without clinical symptoms. The authors found a rising trend of antigenaemia p 24 in the course of HIV infection. The free p 24 antigen was detected in 62% patients with AIDS and only in 10% asymptomatic infections. The investigation confirmed the importance of investigations of the antibody response and p 24 antigenaemia in the prognosis of development of HIV infection and in monitoring of the effect of therapy.
