Dynamika protilátkové odpovĕdi a p 24 antigenémie u HIV-1 infikovaných osob v CSR
[Dynamics of the antibody response and p24 antigenemia in HIV-1 infected individuals in Czechoslovakia]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
2142624
- MeSH
- Acquired Immunodeficiency Syndrome immunology MeSH
- Adult MeSH
- gag Gene Products, Human Immunodeficiency Virus MeSH
- Gene Products, gag analysis MeSH
- HIV Antigens analysis MeSH
- HIV Core Protein p24 MeSH
- HIV Antibodies analysis MeSH
- HIV-1 immunology MeSH
- AIDS-Related Complex immunology MeSH
- Humans MeSH
- Peptides analysis MeSH
- Viral Core Proteins analysis MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- gag Gene Products, Human Immunodeficiency Virus MeSH
- Gene Products, gag MeSH
- HGP-30 peptide, Human immunodeficiency virus-1 MeSH Browser
- HIV Antigens MeSH
- HIV Core Protein p24 MeSH
- HIV Antibodies MeSH
- Peptides MeSH
- Viral Core Proteins MeSH
In a group of 83 anti HIV-1 positive subjects the antibody response against different structural viral proteins was investigated concurrently with assessment of p 24 antigenaemia. Disappearance of antibodies against the capsidal antigen p 24 was recorded in 12% of 42 patients with ARC and AIDS. On the other hand, these antibodies persisted in all 41 asymptomatic infections throughout the three-year investigation period. Disappearance of antibodies against p 17 antigen was proved in 41% of the patients and in 22 subjects without clinical symptoms. The authors found a rising trend of antigenaemia p 24 in the course of HIV infection. The free p 24 antigen was detected in 62% patients with AIDS and only in 10% asymptomatic infections. The investigation confirmed the importance of investigations of the antibody response and p 24 antigenaemia in the prognosis of development of HIV infection and in monitoring of the effect of therapy.
