Increased concentrations of a circulating sodium pump inhibitor in essential hypertension and uraemia and its partial purification from haemofiltrate
Physiologia Bohemoslovaca.
1990 ;
39 (1) :
79-85.
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/pmid02165269
PubMed
2165269
Knihovny.cz E-resources
- MeSH
- Chromatography MeSH
- Chronic Disease MeSH
- Digoxin * MeSH
- Hypertension blood MeSH
- Cardenolides MeSH
- Blood Proteins isolation & purification metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Saponins * MeSH
- Aged MeSH
- Sodium metabolism MeSH
- Sodium-Potassium-Exchanging ATPase antagonists & inhibitors MeSH
- Uremia blood MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- digoxin-like factors MeSH Browser
- Digoxin * MeSH
- Cardenolides MeSH
- Blood Proteins MeSH
- Saponins * MeSH
- Sodium MeSH
- Sodium-Potassium-Exchanging ATPase MeSH
Patients with essential hypertension have 3.2 fold and patients with chronic uraemia 11.7 fold higher serum concentrations of endogenous digitalis-like activity than normotensives (76.3 +/- 9.3 nM). Upon haemodialysis this serum activity drops to almost normal values. A low molecular factor could be partially purified from 4000 l haemofiltrate.
