The effect of soluble glucan derivates on spleen colony-forming units in sublethally irradiated mice
Language English Country United States Media print
Document type Journal Article
PubMed
2262172
DOI
10.1007/bf02821287
Knihovny.cz E-resources
- MeSH
- Colony-Forming Units Assay MeSH
- Glucans pharmacology MeSH
- Hematopoietic Stem Cells drug effects MeSH
- Mice, Inbred A MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Saccharomyces cerevisiae * MeSH
- Spleen cytology drug effects radiation effects MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Glucans MeSH
We examined the effects of 5 soluble derivatives of yeast glucan on the formation of exogenous (CFU-S) and endogenous (E-CFU) colony-forming units in the spleens of sublethally irradiated (60Co, 6.5-7.0 Gy) mice of two inbred strains. For the estimation of CFU-S, glucans were administered intravenously either to donors or recipients of spleen cells 24 h prior to irradiation or removal of the spleen. The number of CFU-S was increased when both the donors and recipients were treated with glucan; the highest increase was obtained with glucans S, P and K. All glucan preparations increased significantly also the number of E-CFU even when administered 90 min after irradiation. There exist differences in the response to the stimulatory effect of glucans among individual mouse strains. Thus, for example, the stimulatory effect of glucan KM on the E-CFU number was significantly more pronounced in strain A/Ph than in strain C57Bl/6.
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