The immunoadjuvant effect of soluble glucan derivatives in mice
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
1823656
DOI
10.1007/bf02814503
Knihovny.cz E-zdroje
- MeSH
- adjuvancia imunologická aplikace a dávkování farmakologie MeSH
- druhová specificita MeSH
- glukany aplikace a dávkování imunologie farmakologie MeSH
- hemaglutininy biosyntéza MeSH
- imunologická odpověď na dávku MeSH
- kvasinky chemie imunologie MeSH
- myši inbrední A MeSH
- myši inbrední C57BL MeSH
- myši inbrední CBA MeSH
- myši MeSH
- ovce MeSH
- tvorba protilátek MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adjuvancia imunologická MeSH
- glukany MeSH
- hemaglutininy MeSH
We examined the effect of soluble derivatives of yeast glucan on the humoral immune response of various strains of inbred mice after administration of different doses according to various schedules. Glucan was injected i.v. or s.c. in a single dose or repeatedly. The immune response was examined by determining the titres of serum hemagglutinins against sheep erythrocytes (SRBC-Ab). The immunoadjuvant effect of glucan derivatives depends on the inbred strain used, on the dose of glucan, mode and time of administration with respect to antigen injection. The results have shown that the stimulatory effect of glucan derivatives occurred already after a single injection, the optimum dose being 10-20 mg/kg. Intravenous injection was more efficient than the subcutaneous one. In some cases, a slight increase of the spleen mass was observed.
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