Interstrain differences in the responsiveness of mice to glucan with respect to hematological effects and manifestations of late damage
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články
- MeSH
- časové faktory MeSH
- druhová specificita MeSH
- erytrocytární znaky účinky léků MeSH
- glukany toxicita MeSH
- granulocyty účinky léků MeSH
- hematopoéza účinky léků MeSH
- inbrední kmeny myší MeSH
- krevní buňky účinky léků MeSH
- myši MeSH
- objem erytrocytu účinky léků MeSH
- tělesná hmotnost účinky léků MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- glukany MeSH
A study was made of the effect of a single s.c. injection of 4 mg glucan in the mouse strains C57BL/10, C3H and a hybrid population of mice. In mice of the strain C57BL/10 high responsiveness was demonstrated, manifested in a long-term increase in the granulocyte counts in the peripheral blood. These effects were accompanied by a fall in the mean red cell volume and the mean corpuscular hemoglobin, a fall in body weight, and mortality. 10 weeks after administration of glucan histology revealed necrotic foci in the livers of animals of the C57BL/10 strain, and an increased amount of the fibrous connective component in the pulmonary interstitium. The strain C3H exhibited a low responsiveness in respect of the hematological indices, while the hybrids did not show any significant response.
Citace poskytuje Crossref.org
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