Vplyv chinidínu na plazmaticků hladinu digoxínu po vynechaní digoxínovej liecby
[The effect of quinidine on digoxin plasma levels after discontinuation of digoxin therapy]
Language Slovak Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
2327086
- MeSH
- Quinidine pharmacology MeSH
- Digoxin administration & dosage blood therapeutic use MeSH
- Drug Interactions MeSH
- Middle Aged MeSH
- Humans MeSH
- Arrhythmias, Cardiac blood drug therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Quinidine MeSH
- Digoxin MeSH
The authors submit a report on the effect of quinidine on plasma digoxin. The investigation was made in 20 patients wit supraventricular dysrhythmia. After initial digoxin treatment they proceeded with quinidine six hours after the last digoxin dose. Although they did not administer digoxin, the digoxin level increased during quinidine treatment in the course of 12 hours from 2.4 +/- 1.6 ng/ml to 3.8 +/- 12.4 ng/ml. The authors draw attention to the importance of following up digoxin levels in the mentioned drug combination which is supposed to prevent serious complication caused by possible digoxin intoxication.
