Cimetidine and ketotifen inhibit stimulated aggregation and histamine liberation from rabbit blood platelets
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
PubMed
2473616
DOI
10.1007/bf02222220
Knihovny.cz E-zdroje
- MeSH
- agregace trombocytů účinky léků MeSH
- cimetidin farmakologie MeSH
- inhibitory agregace trombocytů farmakologie MeSH
- ketotifen farmakologie MeSH
- králíci MeSH
- serotonin metabolismus MeSH
- techniky in vitro MeSH
- trombin farmakologie MeSH
- trombocyty účinky léků imunologie metabolismus MeSH
- uvolňování histaminu účinky léků MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cimetidin MeSH
- inhibitory agregace trombocytů MeSH
- ketotifen MeSH
- serotonin MeSH
- trombin MeSH
The effect of cimetidine and ketotifen was studied on thrombin-stimulated rabbit platelet aggregation as well as on histamine and serotonin liberation. Both drugs inhibited the stimulation of platelets in a dose-dependent way. The effect of ketotifen on stimulated aggregation was about twice that of cimetidine. Stimulated histamine and serotonin liberation was more inhibited by ketotifen than by cimetidine. Both drugs inhibited the liberation of serotonin to a greater extent than that of histamine.
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