Cimetidine and ketotifen inhibit stimulated aggregation and histamine liberation from rabbit blood platelets
Language English Country Switzerland Media print
Document type Journal Article
PubMed
2473616
DOI
10.1007/bf02222220
Knihovny.cz E-resources
- MeSH
- Platelet Aggregation drug effects MeSH
- Cimetidine pharmacology MeSH
- Platelet Aggregation Inhibitors pharmacology MeSH
- Ketotifen pharmacology MeSH
- Rabbits MeSH
- Serotonin metabolism MeSH
- In Vitro Techniques MeSH
- Thrombin pharmacology MeSH
- Blood Platelets drug effects immunology metabolism MeSH
- Histamine Release drug effects MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cimetidine MeSH
- Platelet Aggregation Inhibitors MeSH
- Ketotifen MeSH
- Serotonin MeSH
- Thrombin MeSH
The effect of cimetidine and ketotifen was studied on thrombin-stimulated rabbit platelet aggregation as well as on histamine and serotonin liberation. Both drugs inhibited the stimulation of platelets in a dose-dependent way. The effect of ketotifen on stimulated aggregation was about twice that of cimetidine. Stimulated histamine and serotonin liberation was more inhibited by ketotifen than by cimetidine. Both drugs inhibited the liberation of serotonin to a greater extent than that of histamine.
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