Single K+ currents during differentiation of embryonic muscle cells in vitro
Language English Country Netherlands Media print
Document type Journal Article
PubMed
2510830
DOI
10.1016/0005-2736(89)90284-8
PII: 0005-2736(89)90284-8
Knihovny.cz E-resources
- MeSH
- Adenosine Triphosphate pharmacology MeSH
- Cell Membrane physiology MeSH
- Potassium Channels drug effects physiology MeSH
- Egtazic Acid pharmacology MeSH
- Electric Conductivity MeSH
- Electrophysiology instrumentation methods MeSH
- Cells, Cultured MeSH
- Chick Embryo MeSH
- Membrane Potentials MeSH
- Muscles physiology MeSH
- Tetraethylammonium Compounds pharmacology MeSH
- Tetraethylammonium MeSH
- Animals MeSH
- Check Tag
- Chick Embryo MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adenosine Triphosphate MeSH
- Potassium Channels MeSH
- Egtazic Acid MeSH
- Tetraethylammonium Compounds MeSH
- Tetraethylammonium MeSH
After 3-7 days in culture, chicken myotubes possess five types of K+ channel: two high-conductance channels of 195 and 105 pS which are sensitive to tetraethylammonium (TEA), an ATP-sensitive channel of 64 pS and two low-conductance channels of 40 and 15 pS which are insensitive to TEA and ATP. The same population of channels is to be found in EGTA-treated muscle cells with blocked fusion and, with the exception of the ATP-sensitive channel, also in 1-day-old myoblasts. There are differences between myoblasts and myotubes in the percentage of incidence of individual channel types. High-conductance K+ channels are most frequently to be observed in myotubes, but they are rare in myoblasts and EGTA-treated cells where low-conductance K+ channels predominate.
References provided by Crossref.org
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