• This record comes from PubMed

Effect of Mg2+ on non-quantal acetylcholine release at the mouse neuromuscular junction

. 1989 Sep 11 ; 103 (3) : 293-7.

Language English Country Ireland Media print

Document type Comparative Study, Journal Article

The effects of extracellular concentrations of Mg2+ on the non-quantal release of acetylcholine (ACh) from nerve terminals was studied by extra- and intracellular electrophysiological methods. Anticholinesterase-treated mouse diaphragms were used in vitro. In the presence of Ca2+, the non-quantal release was maximal in the absence of Mg2+ and was inhibited by 3 mmol/l Mg2+. The inhibitory effect of Mg2+ was antagonized by ouabain and was absent in Ca2+-free (EGTA) solutions. The non-quantal release of ACh was found to be more sensitive to inhibition by Mg2+ than the quantal one which was measured as the amplitude of miniature endplate currents.

References provided by Crossref.org

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...