Arachidonic acid-induced inhibition of (Na+K+)-stimulated ATPase in the cerebral cortex and medulla oblongata of young and adult rats
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2851849
Knihovny.cz E-resources
- MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Arachidonic Acid MeSH
- Arachidonic Acids pharmacology MeSH
- Medulla Oblongata enzymology MeSH
- Cerebral Cortex enzymology MeSH
- Sodium-Potassium-Exchanging ATPase antagonists & inhibitors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Arachidonic Acid MeSH
- Arachidonic Acids MeSH
- Sodium-Potassium-Exchanging ATPase MeSH
The effect of arachidonic acid in 5.10(-4) and 5.10(-5) mol.l-1 concentration (as the Na salt, SIGMA) on ouabain-sensitive ATPase (E. C. 3.6.1.3) activity was studied in the cerebral cortex and medulla oblongata of 5-day-old and adult rats. In adult rats, arachidonic acid significantly inhibited ouabain-sensitive ATPase activity in both the cerebral cortex and the medulla oblongata. In 5-day-old rats, only the higher concentration (5.10(-4) mol.l-1) inhibited the enzyme statistically significantly; use of the lower concentration was not followed by any significant changes in Na+-K+-ATPase activity.
