Endogenous digoxin-like factor contributes to the elevation of systemic resistance in rats exposed to high salt intake from prepuberty
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články
PubMed
2856698
Knihovny.cz E-zdroje
- MeSH
- cévní rezistence účinky léků fyziologie MeSH
- deoxykortikosteron * MeSH
- digoxin imunologie MeSH
- hemodynamika účinky léků MeSH
- hypertenze chemicky indukované patofyziologie MeSH
- kardenolidy MeSH
- krevní proteiny imunologie MeSH
- krevní tlak účinky léků fyziologie MeSH
- krysa rodu Rattus MeSH
- pohlavní dospělost fyziologie MeSH
- potkani Wistar MeSH
- saponiny * MeSH
- sodík dietní aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- deoxykortikosteron * MeSH
- digoxin-like factors MeSH Prohlížeč
- digoxin MeSH
- kardenolidy MeSH
- krevní proteiny MeSH
- saponiny * MeSH
- sodík dietní MeSH
The acute administration of anti-digoxin serum (ADS) caused a pronounced blood pressure decrease only in those hypertensive rats that were treated with desoxycorticosterone acetate (DOCA) and 1% saline from prepuberty. This was due to a rapid decrease in systemic resistance which was partially compensated by increased cardiac output. There were no similar effects of ADS in rats treated in the same manner in adulthood only. Different mechanisms might be responsible for blood pressure elevation induced by high salt intake in youth or in adulthood. The participation of endogenous digoxin-like factor in the maintenance of elevated systemic resistance in DOCA-salt hypertensive rats is a typical case.
Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension
Research on Experimental Hypertension in Prague (1966-2009)
The endogenous digitalis-like factor
