Endogenous digoxin-like factor contributes to the elevation of systemic resistance in rats exposed to high salt intake from prepuberty
Language English Country England, Great Britain Media print
Document type Journal Article
PubMed
2856698
Knihovny.cz E-resources
- MeSH
- Vascular Resistance drug effects physiology MeSH
- Desoxycorticosterone * MeSH
- Digoxin immunology MeSH
- Hemodynamics drug effects MeSH
- Hypertension chemically induced physiopathology MeSH
- Cardenolides MeSH
- Blood Proteins immunology MeSH
- Blood Pressure drug effects physiology MeSH
- Rats MeSH
- Sexual Maturation physiology MeSH
- Rats, Wistar MeSH
- Saponins * MeSH
- Sodium, Dietary administration & dosage MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Desoxycorticosterone * MeSH
- digoxin-like factors MeSH Browser
- Digoxin MeSH
- Cardenolides MeSH
- Blood Proteins MeSH
- Saponins * MeSH
- Sodium, Dietary MeSH
The acute administration of anti-digoxin serum (ADS) caused a pronounced blood pressure decrease only in those hypertensive rats that were treated with desoxycorticosterone acetate (DOCA) and 1% saline from prepuberty. This was due to a rapid decrease in systemic resistance which was partially compensated by increased cardiac output. There were no similar effects of ADS in rats treated in the same manner in adulthood only. Different mechanisms might be responsible for blood pressure elevation induced by high salt intake in youth or in adulthood. The participation of endogenous digoxin-like factor in the maintenance of elevated systemic resistance in DOCA-salt hypertensive rats is a typical case.
Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension
Research on Experimental Hypertension in Prague (1966-2009)
The endogenous digitalis-like factor
