The effect of isoprenaline on the phospholipid content of the compact and spongious musculature of the carp ventricular myocardium
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články
- MeSH
- Cyprinidae metabolismus MeSH
- fosfolipidy metabolismus MeSH
- isoprenalin farmakologie MeSH
- kapři metabolismus MeSH
- myokard metabolismus MeSH
- plasmalogeny farmakologie MeSH
- techniky in vitro MeSH
- tělesná hmotnost účinky léků MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- choline plasmalogens MeSH Prohlížeč
- fosfolipidy MeSH
- isoprenalin MeSH
- plasmalogeny MeSH
1. After a single injection of 40 mg kg-1 of isoprenaline to the carp, lysophospholipids appear in the tissue of the heart ventricle, ethanolamine plasmalogens increase and choline plasmalogens decrease; phosphatidylinositol is lowered in the spongious layer only. 2. Daily administration of 5 mg kg-1 of the drug leads, after 5 doses, to a dramatic decrease of the diphosphatidylglycerol content; during the subsequent 5 and 10 doses a return to normal values occurs. Shifts in plasmalogens are similar to those found after a single high dose. Some other phospholipids change significantly. 3. All changes reveal that the spongious musculature is more sensitive to the drug than the compact one.
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