The effect of isoprenaline on the phospholipid content of the compact and spongious musculature of the carp ventricular myocardium
Language English Country England, Great Britain Media print
Document type Journal Article
- MeSH
- Cyprinidae metabolism MeSH
- Phospholipids metabolism MeSH
- Isoproterenol pharmacology MeSH
- Carps metabolism MeSH
- Myocardium metabolism MeSH
- Plasmalogens pharmacology MeSH
- In Vitro Techniques MeSH
- Body Weight drug effects MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- choline plasmalogens MeSH Browser
- Phospholipids MeSH
- Isoproterenol MeSH
- Plasmalogens MeSH
1. After a single injection of 40 mg kg-1 of isoprenaline to the carp, lysophospholipids appear in the tissue of the heart ventricle, ethanolamine plasmalogens increase and choline plasmalogens decrease; phosphatidylinositol is lowered in the spongious layer only. 2. Daily administration of 5 mg kg-1 of the drug leads, after 5 doses, to a dramatic decrease of the diphosphatidylglycerol content; during the subsequent 5 and 10 doses a return to normal values occurs. Shifts in plasmalogens are similar to those found after a single high dose. Some other phospholipids change significantly. 3. All changes reveal that the spongious musculature is more sensitive to the drug than the compact one.
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