Influence of thyroxine and propylthiouracil administration on the intake of maternal milk in sucklings of the laboratory rat
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2931733
Knihovny.cz E-resources
- MeSH
- Rats, Inbred Strains MeSH
- Animals, Suckling physiology MeSH
- Rats MeSH
- Lactation MeSH
- Milk * MeSH
- Ocular Physiological Phenomena MeSH
- Drinking drug effects MeSH
- Propylthiouracil pharmacology MeSH
- Strontium Radioisotopes metabolism MeSH
- Animal Population Groups physiology MeSH
- Pregnancy MeSH
- Body Weight MeSH
- Thyroxine pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Propylthiouracil MeSH
- Strontium Radioisotopes MeSH
- Thyroxine MeSH
Young laboratory rats received a daily subcutaneous injection of thyroxine (T4) and propylthiouracil (PTU) in saline, from birth until the period of spontaneous weaning. The rate of growth and the time of eye opening as well as the spontaneous weaning was assessed. The intake of maternal milk was followed directly, i.e. by the transport of 85Sr in maternal milk from the maternal body to the sucklings. In the young treated with T4 the eyes opened earlier than in the young treated with PTU. The body mass differed in both groups between the 4th and 20th day of life (the T4 pups were heavier). The 85Sr transfer in maternal milk was higher in the PTU young from the 22nd day of life. The PTU sucklings weaned spontaneously one week later than those receiving T4. A hypothesis has been proposed on the primary significance of maturation of oral mechanisms of sucking for spontaneous weaning.
Effect of hypo- and hyperthyroid states on phospholipid composition in developing rat heart
