Prevalence and Drivers of COVID-19 Vaccine Hesitancy among Czech University Students: National Cross-Sectional Study
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
Grantová podpora
MUNI/IGA/1543/2020
Masarykova Univerzita
MUNI/A/1608/2020
Masarykova Univerzita
LTC20031
Ministerstvo Školství, Mládeže a Tělovýchovy
PubMed
34579185
PubMed Central
PMC8470400
DOI
10.3390/vaccines9090948
PII: vaccines9090948
Knihovny.cz E-zdroje
- Klíčová slova
- COVID-19 vaccines, Czech Republic, cross-sectional studies, decision making, mass vaccination, university students, vaccine hesitancy,
- Publikační typ
- časopisecké články MeSH
BACKGROUND: university students are believed to retain the highest levels of health literacy. They are perceived as the opinion leaders within their communities; therefore, their health-related beliefs and attitudes are deemed important for public health campaigns. This study aimed to investigate the COVID-19 vaccine hesitancy drivers among university students in the Czech Republic. METHODS: a cross-sectional study using a self-administered questionnaire was carried out in the weeks before the unrestricted vaccine deployment to Czech adults. The questionnaire had 21 multiple-choice items stratified in 4 categories; demographic characteristics, COVID-19-related anamnesis and influenza vaccine experience, attitudes towards COVID-19 vaccination, and the possible drivers of COVID-19 vaccine hesitancy suggested by the WHO-SAGE. RESULTS: out of the 1351 included students, 66.8% were females, 84.5% were Czech nationals, and 40.6% enrolled in healthcare programs. The overall COVID-19 vaccine acceptance level was 73.3%, 19.3% of participants were vaccine-resistant, and only 7.4% were vaccine-hesitant. Trust in the pharmaceutical industry, trust in healthcare providers, and perceived knowledge sufficiency predicted higher odds of vaccine acceptance. In contrast, media and social media, personal beliefs, immunity misconception, previous COVID-19 infection, and suspicions about novel vaccines and the local availability predicted higher odds of vaccine hesitancy. CONCLUSIONS: The findings of this study predict a fair probability to achieve community immunity (herd immunity) among the target population group. The primary prevention strategies in the Czech Republic need to be culturally sensitive and inclusive for foreign nationals. As one-quarter of the participating students are dependent on vaccine safety data, this study findings support the call for independent studies evaluating the side effects of COVID-19 vaccines.
Zobrazit více v PubMed
Vaccines and Immunization. [(accessed on 6 February 2021)]. Available online: https://www.who.int/health-topics/vaccines-and-immunization#tab=tab_1.
Gavi—The Vaccine Alliance In Immunisation: Strengthening Primary Healthcare for Universal Health Coverage Immunisation-A Platform for Strengthening Primary Health Care. [(accessed on 1 July 2021)]. Available online: www.gavi.org.
National Institutes of Health (NIH) Health Literacy. Clear Communication. [(accessed on 20 August 2021)]; Available online: https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/clear-communication/health-literacy.
Riad A., Abdulqader H., Morgado M., Domnori S., Koščík M., Mendes J., Klugar M., Kateeb E., Iads-Score O.B.O. Global Prevalence and Drivers of Dental Students’ COVID-19 Vaccine Hesitancy. Vaccines. 2021;9:566. doi: 10.3390/vaccines9060566. PubMed DOI PMC
Alawia R., Riad A., Kateeb E. Knowledge and attitudes among dental students about COVID-19 and its precautionary measures: A cross-sectional study. J. Oral. Med. Oral. Surg. 2021;27:17. doi: 10.1051/mbcb/2020056. DOI
Alawia R., Riad A., Kateeb E. Risk perception and readiness of dental students to treat patients amid COVID-19: Implication for dental education. Oral. Dis. 2020 doi: 10.1111/odi.13593. early review. PubMed DOI PMC
Yildiz S., Dogan B. Self Reported Dental Health Attitudes and Behaviour of Dental Students in Turkey. Eur. J. Dent. 2011;5:253–259. doi: 10.1055/s-0039-1698889. PubMed DOI PMC
Åstrøm A.N., Jackson W., Mwangosi I.E.A.T. Knowledge, beliefs and behavior related to oral health among Tanzanian and Ugandan teacher trainees. Acta Odontol. Scand. 2000;58:11–18. doi: 10.1080/000163500429370. PubMed DOI
Vozikis A., Drivas K., Milioris K. Health literacy among university students in Greece: Determinants and association with self-perceived health, health behaviours and health risks. Arch. Public Health. 2014;72:15. doi: 10.1186/2049-3258-72-15. PubMed DOI PMC
Juvinyà-Canal D., Suñer-Soler R., Porquet A.B., Vernay M., Blanchard H., Bertran-Noguer C. Health Literacy among Health and Social Care University Students. Int. J. Environ. Res. Public Health. 2020;17:2273. doi: 10.3390/ijerph17072273. PubMed DOI PMC
Riad A., Klugar M., Krsek M. COVID-19-Related Oral Manifestations: Early Disease Features? Oral. Dis. 2020;30 doi: 10.1111/odi.13516. PubMed DOI PMC
Hocková B., Riad A., Valky J., Šulajová Z., Stebel A., Slávik R., Bečková Z., Pokorná A., Klugarová J., Klugar M. Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases. J. Clin. Med. 2021;10:581. doi: 10.3390/jcm10040581. PubMed DOI PMC
Riad A., Kassem I., Hockova B., Badrah M., Klugar M. Tongue Ulcers Associated with SARS-COV-2 Infection: A case-series. Oral. Dis. 2020;25 doi: 10.1111/odi.13635. PubMed DOI
Riad A., Kassem I., Hockova B., Badrah M., Klugar M. Halitosis in COVID-19 patients. Spéc. Care Dent. 2021;41:282–285. doi: 10.1111/scd.12547. PubMed DOI PMC
Riad A., Gad A., Hockova B., Klugar M. Oral candidiasis in non-severe COVID-19 patients: Call for antibiotic stewardship. Oral. Surg. 2020;9 doi: 10.1111/ors.12561. PubMed DOI PMC
Riad A., Gomaa E., Hockova B., Klugar M. Oral candidiasis of COVID-19 patients: Case report and review of evidence. J. Cosmet. Dermatol. 2021;20:1580–1584. doi: 10.1111/jocd.14066. PubMed DOI PMC
Riad A., Kassem I., Badrah M., Klugar M. Acute parotitis as a presentation of COVID-19? Oral. Dis. 2020 doi: 10.1111/odi.13571. PubMed DOI
Riad A., Kassem I., Badrah M., Klugar A.M. The manifestation of oral mucositis in COVID-19 patients: A case-series. Dermatol. Ther. 2020;33:e14479. doi: 10.1111/dth.14479. PubMed DOI PMC
Riad A., Kassem I., Issa J., Badrah M., Klugar M. Angular cheilitis of COVID-19 patients: A case-series and literature review. Oral. Dis. 2020;23 doi: 10.1111/odi.13675. PubMed DOI PMC
Riad A., Kassem I., Stanek J., Badrah M., Klugarova J., Klugar M. Aphthous stomatitis in COVID-19 patients: Case-series and literature review. Dermatol. Ther. 2021;34:e14735. doi: 10.1111/dth.14735. PubMed DOI PMC
Al-Khanati N.M., Riad A., Sahloul M.E., Klugar M. Aphthous-like stomatitis of COVID-19 patients. Braz. J. Oral. Sci. 2020;19:e201354. doi: 10.20396/bjos.v19i0.8661354. DOI
Wollina U., Karadağ A.S., Rowland-Payne C., Chiriac A., Lotti T. Cutaneous signs in COVID -19 patients: A review. Dermatol. Ther. 2020;33 doi: 10.1111/dth.13549. PubMed DOI PMC
Wollina U. Challenges of COVID-19 pandemic for dermatology. Dermatol. Ther. 2020;33:e13430. doi: 10.1111/dth.13430. PubMed DOI PMC
Abrams J.Y., Godfred-Cato S.E., Oster M.E., Chow E., Koumans E.H., Bryant B., Leung J.W., Belay E.D. Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review. J. Pediatr. 2020;226:45–54.e1. doi: 10.1016/j.jpeds.2020.08.003. PubMed DOI PMC
Ackerson B.K., Sy L.S., Glenn S.C., Qian L., Park C.H., Riewerts R.J., Jacobsen S.J. Pediatric Vaccination During the COVID-19 Pandemic. Pediatrics. 2021;148:e2020047092. doi: 10.1542/peds.2020-047092. PubMed DOI
Santoli J.M., Lindley M.C., DeSilva M.B., Kharbanda E.O., Daley M.F., Galloway L., Gee J., Glover M., Herring B., Kang Y., et al. Effects of the COVID-19 Pandemic on Routine Pediatric Vaccine Ordering and Administration—United States, 2020. MMWR Morb. Mortal. Wkly. Rep. 2020;69:591–593. doi: 10.15585/mmwr.mm6919e2. PubMed DOI
EurekAlert Child Vaccination Rates Declined during COVID-19 Pandemic. Science News. [(accessed on 1 July 2021)]. Available online: https://www.eurekalert.org/pub_releases/2021-04/kp-cvr041521.php.
MacDonald N.E. Vaccine hesitancy: Definition, scope and determinants. Vaccine. 2015;33:4161–4164. doi: 10.1016/j.vaccine.2015.04.036. PubMed DOI
Geoghegan S., O’Callaghan K.P., Offit P.A. Vaccine Safety: Myths and Misinformation. Front. Microbiol. 2020;11:372. doi: 10.3389/fmicb.2020.00372. PubMed DOI PMC
Taylor B., Miller E., Farrington C.P., Petropoulos M.-C., Favot-Mayaud I., Li J., A Waight P. Autism and measles, mumps, and rubella vaccine: No epidemiological evidence for a causal association. Lancet. 1999;353:2026–2029. doi: 10.1016/S0140-6736(99)01239-8. PubMed DOI
Ten Health Issues WHO Will Tackle This Year—World Health Organization. [(accessed on 1 July 2021)]. Available online: https://www.who.int/news-room/spotlight/ten-threats-to-global-health-in-2019.
Patel M., Lee A.D., Clemmons N.S., Redd S.B., Poser S., Blog D., Zucker J.R., Leung J., Link-Gelles R., Pham H., et al. National Update on Measles Cases and Outbreaks—United States, January 1–October 1, 2019. MMWR. Morb. Mortal. Wkly. Rep. 2019;68:893–896. doi: 10.15585/mmwr.mm6840e2. PubMed DOI PMC
A Comprehensive Guide to Vaccination in the Czech Republic: Updated 5 May 2021—Prague, Czech Republic. [(accessed on 1 July 2021)]. Available online: https://www.expats.cz/czech-news/article/vaccination-in-the-czech-republic-all-you-need-to-know.
Ministerstvo Vnitra Vaccination Timeline. Covid Portál. [(accessed on 20 June 2021)]; Available online: https://covid.gov.cz/en/situations/register-vaccination/vaccination-timeline.
KoBoToolbox.org KoBoToolbox. Harvard Humanitarian Initiative. [(accessed on 15 August 2021)]. Available online: https://support.kobotoolbox.org/welcome.html.
Saied S.M., Saied E.M., Kabbash I.A., Abdo S.A.E. Vaccine hesitancy: Beliefs and barriers associated with COVID-19 vaccination among Egyptian medical students. J. Med. Virol. 2021;93:4280–4291. doi: 10.1002/jmv.26910. PubMed DOI PMC
Szmyd B., Bartoszek A., Karuga F.F., Staniecka K., Błaszczyk M., Radek M. Medical Students and SARS-CoV-2 Vaccination: Attitude and Behaviors. Vaccines. 2021;9:128. doi: 10.3390/vaccines9020128. PubMed DOI PMC
Lucia V.C., Kelekar A., Afonso N.M. COVID-19 vaccine hesitancy among medical students. J. Public Health. 2020:fdaa230. doi: 10.1093/pubmed/fdaa230. PubMed DOI PMC
Masaryk University Clubs & Associations at the Faculty of Medicine. [(accessed on 20 June 2021)]. Available online: https://www.muni.cz/en/students/student-clubs-associations/contact-1/faculty-of-medicine.
European Comission Czech Republic: Tertiary Education. EURYDICE. [(accessed on 20 June 2021)]. Available online: https://eacea.ec.europa.eu/national-policies/eurydice/content/higher-education-21_cs.
McHugh M.L. Interrater reliability: The kappa statistic. Biochem. Med. 2012;22:276–282. doi: 10.11613/BM.2012.031. PubMed DOI PMC
Strategic Advisory Group of Experts on Immunization (SAGE) Vaccine Hesitancy Survey Questions Related to SAGE Vaccine Hesitancy Matrix. [(accessed on 14 March 2021)]. Available online: https://www.who.int/immunization/programmes_systems/Survey_Questions_Hesitancy.pdf.
World Medical Association World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA. 2013;310:2191–2194. doi: 10.1001/jama.2013.281053. PubMed DOI
Von Elm E., Altman D.G., Egger M., Pocock S.J., Gøtzsche P.C., Vandenbroucke J.P. Strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. Br. Med. J. 2007;335:806–808. doi: 10.1136/bmj.39335.541782.AD. PubMed DOI PMC
GDPR General Data Protection Regulation, Complete Guide to GDPR Compliance. [(accessed on 1 July 2021)]. Available online: https://gdpr.eu/
SPSS Inc. IBM SPSS Statistics 27. [(accessed on 14 October 2020)]. Available online: https://www.ibm.com/support/pages/node/3006603.
Al-Mulla R., Abu-Madi M., Talafha Q., Tayyem R., Abdallah A. COVID-19 Vaccine Hesitancy in a Representative Education Sector Population in Qatar. Vaccines. 2021;9:665. doi: 10.3390/vaccines9060665. PubMed DOI PMC
Tavolacci M., Dechelotte P., Ladner J. COVID-19 Vaccine Acceptance, Hesitancy, and Resistancy among University Students in France. Vaccines. 2021;9:654. doi: 10.3390/vaccines9060654. PubMed DOI PMC
Synnott K. College Students’ COVID-19 Vaccine Hesitancy. SSRN Electron J. 2020 doi: 10.2139/ssrn.3753756. DOI
Sallam M., Dababseh D., Eid H., Hasan H., Taim D., Al-Mahzoum K., Al-Haidar A., Yaseen A., Ababneh N., Assaf A., et al. Low COVID-19 Vaccine Acceptance Is Correlated with Conspiracy Beliefs among University Students in Jordan. Int. J. Environ. Res. Public Health. 2021;18:2407. doi: 10.3390/ijerph18052407. PubMed DOI PMC
Barello S., Nania T., Dellafiore F., Graffigna G., Caruso R. ‘Vaccine hesitancy’ among university students in Italy during the COVID-19 pandemic. Eur. J. Epidemiol. 2020;35:781–783. doi: 10.1007/s10654-020-00670-z. PubMed DOI PMC
Czech Statistical Office Statistical Yearbook of the Czech Republic—2020. Yearsbooks. [(accessed on 1 July 2020)]. Available online: https://www.czso.cz/csu/czso/statistical-yearbook-of-the-czech-republic-2020.
Patelarou E., Galanis P., Mechili E.A., Argyriadi A., Argyriadis A., Asimakopoulou E., Brokaj S., Bucaj J., Carmona-Torres J.M., Cobo-Cuenca A.I., et al. Factors influencing nursing students’ intention to accept COVID-19 vaccination: A pooled analysis of seven European countries. Nurse Educ. Today. 2021;104:105010. doi: 10.1016/j.nedt.2021.105010. PubMed DOI PMC
Sovicova M., Zibolenova J., Svihrova V., Hudeckova H. Odds Ratio Estimation of Medical Students’ Attitudes towards COVID-19 Vaccination. Int. J. Environ. Res. Public Health. 2021;18:6815. doi: 10.3390/ijerph18136815. PubMed DOI PMC
da Silva D.T., Biello K., Lin W., Valente P., Mayer K., Hightow-Weidman L., Bauermeister J. COVID-19 Vaccine Acceptance among an Online Sample of Sexual and Gender Minority Men and Transgender Women. Vaccines. 2021;9:204. doi: 10.3390/vaccines9030204. PubMed DOI PMC
Walker A., Zhang T., Peng X.-Q., Ge J.-J., Gu H., You H. Vaccine Acceptance and Its Influencing Factors: An Online Cross-Sectional Study among International College Students Studying in China. Vaccines. 2021;9:585. doi: 10.3390/vaccines9060585. PubMed DOI PMC
Alabdulla M., Reagu S.M., Al-Khal A., Elzain M., Jones R.M. COVID-19 vaccine hesitancy and attitudes in Qatar: A national cross-sectional survey of a migrant-majority population. Influenza Other Respir. Viruses. 2021;15:361–370. doi: 10.1111/irv.12847. PubMed DOI PMC
Ministry of Health of the Czech Republic (MZCR) Vaccinating foreign nationals against COVID-19 in CZ. Aktuální informace o COVID-19. [(accessed on 1 July 2021)]. Available online: https://koronavirus.mzcr.cz/en/vaccinating-foreign-nationals-against-covid-19-in-cz/
Jain J., Saurabh S., Kumar P., Verma M.K., Goel A.D., Gupta M.K., Bhardwaj P., Raghav P.R. COVID-19 vaccine hesitancy among medical students in India. Epidemiol. Infect. 2021;149:1–28. doi: 10.1017/S0950268821001205. PubMed DOI PMC
Kelekar A.K., Lucia V.C., Afonso N.M., Mascarenhas A.K. COVID-19 vaccine acceptance and hesitancy among dental and medical students. J. Am. Dent. Assoc. 2021;152:596–603. doi: 10.1016/j.adaj.2021.03.006. PubMed DOI PMC
Papagiannis D., Tsimtsiou Z., Chatzichristodoulou I., Adamopoulou M., Kallistratos I., Pournaras S., Arvanitidou M., Rachiotis G. Hepatitis B Virus Vaccination Coverage in Medical, Nursing, and Paramedical Students: A Cross-Sectional, Multi-Centered Study in Greece. Int. J. Environ. Res. Public Health. 2016;13:323. doi: 10.3390/ijerph13030323. PubMed DOI PMC
Loulergue P., Fonteneau L., Armengaud J.-B., Momcilovic S., Levy-Brühl D., Launay O., Guthmann J.-P. Vaccine coverage of healthcare students in hospitals of the Paris region in 2009: The Studyvax Survey. Vaccine. 2013;31:2835–2838. doi: 10.1016/j.vaccine.2013.04.004. PubMed DOI
La Vecchia C., Negri E., Alicandro G., Scarpino V. Attitudes towards influenza vaccine and a potential COVID-19 vaccine in Italy and differences across occupational groups, September 2020. Med. Lav. 2020;111:445–448. doi: 10.23749/mdl.v111i6.10813. PubMed DOI PMC
Gostin L.O., Salmon D.A. The Dual Epidemics of COVID-19 and Influenza. JAMA. 2020;324:335–336. doi: 10.1001/jama.2020.10802. PubMed DOI
Gerussi V., Peghin M., Palese A., Bressan V., Visintini E., Bontempo G., Graziano E., De Martino M., Isola M., Tascini C. Vaccine Hesitancy among Italian Patients Recovered from COVID-19 Infection towards Influenza and Sars-Cov-2 Vaccination. Vaccines. 2021;9:172. doi: 10.3390/vaccines9020172. PubMed DOI PMC
Olanipekun T., Abe T., Effoe V., Kagbo-Kue S., Chineke I., Ivonye C., Bakinde N. Attitudes and Perceptions Towards Coronavirus Disease 2019 (COVID-19) Vaccine Acceptance Among Recovered African American Patients. J. Gen. Intern. Med. 2021;2021:1–3. doi: 10.1007/s11606-021-06787-5. PubMed DOI PMC
Sheikh A., McMenamin J., Taylor B., Robertson C. SARS-CoV-2 Delta VOC in Scotland: Demographics, risk of hospital admission, and vaccine effectiveness. Lancet. 2021;397:2461–2462. doi: 10.1016/S0140-6736(21)01358-1. PubMed DOI PMC
Robert M., Jason H., Czech P.M. Names Fourth Health Minister Amid Sputnik Vaccine Strife. Reuters. [(accessed on 1 July 2021)]. Available online: https://www.reuters.com/article/us-czech-government/czech-pm-names-fourth-health-minister-amid-sputnik-vaccine-strife-idUSKBN2BU110.
Czech Civil Society Fights Back Against Fake News. DW. [(accessed on 1 July 2021)]. Available online: https://www.dw.com/en/czech-civil-society-fights-back-against-fake-news/a-53758412.
NELEŽ. [(accessed on 1 July 2021)]. Available online: https://www.nelez.cz/en/home-eng/
Fakescape! [(accessed on 1 July 2021)]. Available online: https://www.fakescape.cz/
Hua J., Shaw R. Corona Virus (COVID-19) “Infodemic” and Emerging Issues through a Data Lens: The Case of China. Int. J. Environ. Res. Public Health. 2020;17:2309. doi: 10.3390/ijerph17072309. PubMed DOI PMC
Griffith J., Marani H., Monkman H. COVID-19 Vaccine Hesitancy in Canada: Content Analysis of Tweets Using the Theoretical Domains Framework. J. Med. Internet Res. 2021;23:e26874. doi: 10.2196/26874. PubMed DOI PMC
Bonnevie E., Gallegos-Jeffrey A., Goldbarg J., Byrd B., Smyser J. Quantifying the rise of vaccine opposition on Twitter during the COVID-19 pandemic. J. Commun. Health. 2021;14:12–19. doi: 10.1080/17538068.2020.1858222. DOI
Riad A., Pokorná A., Attia S., Klugarová J., Koščík M., Klugar M. Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic. J. Clin. Med. 2021;10:1428. doi: 10.3390/jcm10071428. PubMed DOI PMC
Riad A., Sağıroğlu D., Üstün B., Pokorná A., Klugarová J., Attia S., Klugar M. Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey. J. Clin. Med. 2021;10:2629. doi: 10.3390/jcm10122629. PubMed DOI PMC
Riad A., Pokorná A., Mekhemar M., Conrad J., Klugarová J., Koščík M., Klugar M., Attia S. Safety of ChAdOx1 nCoV-19 Vaccine: Independent Evidence from Two EU States. Vaccines. 2021;9:673. doi: 10.3390/vaccines9060673. PubMed DOI PMC
Riad A., Schünemann H., Attia S., Peričić T., Žuljević M., Jürisson M., Kalda R., Lang K., Morankar S., Yesuf E., et al. COVID-19 Vaccines Safety Tracking (CoVaST): Protocol of a Multi-Center Prospective Cohort Study for Active Surveillance of COVID-19 Vaccines’ Side Effects. Int. J. Environ. Res. Public Health. 2021;18:7859. doi: 10.3390/ijerph18157859. PubMed DOI PMC
Jęśkowiak I., Wiatrak B., Grosman-Dziewiszek P., Szeląg A. The Incidence and Severity of Post-Vaccination Reactions after Vaccination against COVID-19. Vaccines. 2021;9:502. doi: 10.3390/vaccines9050502. PubMed DOI PMC
Collaborating in Response to COVID-19: Editorial and Methods Initiatives Across Cochrane. John Wiley & Sons, Inc.; Hoboken, NJ, USA: 2020. Collaborating in response to COVID-19: Editorial and methods initiatives across Cochrane. DOI
Klugar M., Riad A., Mekhemar M., Conrad J., Buchbender M., Howaldt H.-P., Attia S. Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers. Biology. 2021;10:752. doi: 10.3390/biology10080752. PubMed DOI PMC
Eurostat International Standard Classification of Education (ISCED). Statistics Explained. [(accessed on 1 July 2021)]. Available online: https://ec.europa.eu/eurostat/statistics-explained/index.php?title=International_Standard_Classification_of_Education_(ISCED)
Nuclear Anxiety Amid the Russian-Ukrainian War 2022 (RUW-22): Descriptive Cross-Sectional Study