Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic

. 2021 Apr 01 ; 10 (7) : . [epub] 20210401

Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid33916020

Grantová podpora
MUNI/IGA/1543/2020 Masarykova Univerzita
MUNI/A/1608/2020 Masarykova Univerzita
LTC20031 Ministerstvo Školství, Mládeže a Tělovýchovy
LM2018128 Ministerstvo Školství, Mládeže a Tělovýchovy
CZ.02.1.01/0.0/0.0/16_013/0001826 European Regional Development Fund

BACKGROUND: COVID-19 vaccine side effects have a fundamental role in public confidence in the vaccine and its uptake process. Thus far, the evidence on vaccine safety has exclusively been obtained from the manufacturer-sponsored studies; therefore, this study was designed to provide independent evidence on Pfizer-BioNTech COVID-19 vaccine side effects. METHODS: A cross-sectional survey-based study was carried out between January and February 2021 to collect data on the side effects following the COVID-19 vaccine among healthcare workers in the Czech Republic. The study used a validated questionnaire with twenty-eight multiple-choice items covering the participants' demographic data, medical anamneses, COVID-19-related anamneses, general, oral, and skin-related side effects. RESULTS: Injection site pain (89.8%), fatigue (62.2%), headache (45.6%), muscle pain (37.1%), and chills (33.9%) were the most commonly reported side effects. All the general side effects were more prevalent among the ≤43-year-old group, and their duration was mainly one day (45.1%) or three days (35.8%) following the vaccine. Antihistamines were the most common drugs associated with side effects, thus requiring further investigation. The people with two doses were generally associated with a higher frequency of side effects. CONCLUSIONS: The distribution of side effects among Czech healthcare workers was highly consistent with the manufacturer's data, especially in terms of their association with the younger age group and the second dose. The overall prevalence of some local and systemic side effects was higher than the manufacturer's report. Further independent studies on vaccine safety are strongly required to strengthen public confidence in the vaccine.

Zobrazit více v PubMed

Butler R., MacDonald N.E., Eskola J., Liang X., Chaudhuri M., Dube E., Gellin B., Goldstein S., Larson H., Manzo M.L., et al. Diagnosing the determinants of vaccine hesitancy in specific subgroups: The Guide to Tailoring Immunization Programmes (TIP) Vaccine. 2015;33:4176–4179. doi: 10.1016/j.vaccine.2015.04.038. PubMed DOI

Harrison E.A., Wu J.W. Vaccine confidence in the time of COVID-19. Eur. J. Epidemiol. 2020;35:325–330. doi: 10.1007/s10654-020-00634-3. PubMed DOI PMC

Dror A.A., Eisenbach N., Taiber S., Morozov N.G., Mizrachi M., Zigron A., Srouji S., Sela E. Vaccine hesitancy: The next challenge in the fight against COVID-19. Eur. J. Epidemiol. 2020;35:775–779. doi: 10.1007/s10654-020-00671-y. PubMed DOI PMC

Luyten J., Bruyneel L., van Hoek A.J. Assessing vaccine hesitancy in the UK population using a generalized vaccine hesitancy survey instrument. Vaccine. 2019;37:2494–2501. doi: 10.1016/j.vaccine.2019.03.041. PubMed DOI

Szmyd B., Bartoszek A., Karuga F.F., Staniecka K., Błaszczyk M., Radek M. Medical Students and SARS-CoV-2 Vaccination: Attitude and Behaviors. Vaccines. 2021;9:128. doi: 10.3390/vaccines9020128. PubMed DOI PMC

Szmyd B., Karuga F.F., Bartoszek A., Staniecka K., Siwecka N., Bartoszek A., Błaszczyk M., Radek M. Attitude and Behaviors towards SARS-CoV-2 Vaccination among Healthcare Workers: A Cross-Sectional Study from Poland. Vaccines. 2021;9:218. doi: 10.3390/vaccines9030218. PubMed DOI PMC

Jarrett C., Wilson R., O’Leary M., Eckersberger E., Larson H.J., Eskola J., Liang X., Chaudhuri M., Dube E., Gellin B., et al. Strategies for addressing vaccine hesitancy—A systematic review. Vaccine. 2015;33:4180–4190. doi: 10.1016/j.vaccine.2015.04.040. PubMed DOI

Attia S., Howaldt H.-P. Impact of COVID-19 on the Dental Community: Part I before Vaccine (BV) J. Clin. Med. 2021;10:288. doi: 10.3390/jcm10020288. PubMed DOI PMC

Sawires L. Effects of the Influenza Vaccine on the Oral Cavity. [(accessed on 16 December 2020)];2018 Available online: https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=1306&context=honorstheses.

Gonçalves A.K., Cobucci R.N., Rodrigues H.M., De Melo A.G., Giraldo P.C. Safety, tolerability and side effects of human papillomavirus vaccines: A systematic quantitative review. Braz. J. Infect. Dis. 2014;18:651–659. doi: 10.1016/j.bjid.2014.02.005. PubMed DOI PMC

Riad A., Klugar M., Krsek M. COVID-19 Related Oral Manifestations, Early Disease Features? Oral Dis. 2020 doi: 10.1111/odi.13516. PubMed DOI PMC

Riad A., Kassem I., Issa J., Badrah M., Klugar M. Angular cheilitis of COVID-19 patients: A case-series and literature review. Oral Dis. 2020 doi: 10.1111/odi.13675. PubMed DOI PMC

Riad A., Kassem I., Stanek J., Badrah M., Klugarova J., Klugar M. Aphthous Stomatitis in COVID-19 Patients: Case-series and Literature Review. Dermatol. Ther. 2021;34:e14735. doi: 10.1111/dth.14735. PubMed DOI PMC

Riad A., Kassem I., Hockova B., Badrah M., Klugar M. Tongue ulcers associated with SARS-CoV-2 infection: A case series. Oral Dis. 2020 doi: 10.1111/odi.13635. PubMed DOI

Hocková B., Riad A., Valky J., Šulajová Z., Stebel A., Slávik R., Bečková Z., Pokorná A., Klugarová J., Klugar M. Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases. J. Clin. Med. 2021;10:581. doi: 10.3390/jcm10040581. PubMed DOI PMC

Riad A., Gad A., Hockova B., Klugar M. Oral candidiasis in non-severe COVID-19 patients: Call for antibiotic stewardship. Oral Surg. 2020 doi: 10.1111/ors.12561. PubMed DOI PMC

Riad A., Kassem I., Badrah M., Klugar M. The manifestation of oral mucositis in COVID-19 patients: A case-series. Dermatol. Ther. 2020;33 doi: 10.1111/dth.14479. PubMed DOI PMC

Maspero C., Abate A., Cavagnetto D., El Morsi M., Fama A., Farronato M. Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic. J. Clin. Med. 2020;9:1891. doi: 10.3390/jcm9061891. PubMed DOI PMC

Centres for Diseases Control and Prevention (CDC) Reactions and Adverse Events of the Pfizer-BioNTech COVID-19 Vaccine. [(accessed on 7 March 2021)]; Available online: https://www.cdc.gov/vaccines/covid-19/info-by-product/pfizer/reactogenicity.html.

Masaryk University Oral Side Effects of COVID-19 Vaccine (OSECV) [(accessed on 24 February 2021)];2021 Available online: https://clinicaltrials.gov/ct2/show/NCT04706156.

Von Elm E., Altman D.G., Egger M., Pocock S.J., Gøtzsche P.C., Vandenbroucke J.P. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for reporting observational studies. Ann. Int. Med. 2007;147:573–577. doi: 10.7326/0003-4819-147-8-200710160-00010. PubMed DOI

Ústav Zdravotnických Informací a Statistiky České Republiky (ÚZIS ČR) Systém Hlášení Nežádoucích Událostí (SHNU) [(accessed on 8 March 2021)];2021 Available online: https://shnu.uzis.cz/

CZECRIN Czech Clinical Research Infrastructure Network. [(accessed on 2 March 2021)]; Available online: https://czecrin.cz/en/home/

Proton Technologies AG General Data Protection Regulation (GDPR) Compliance Guidelines. HORIZON 2020—Project REP-791727-1. [(accessed on 1 May 2020)]; Available online: https://gdpr.eu/

Ministry of Interior—Czech Republic Who Will Be Vaccinated First? Covid Portál. [(accessed on 2 March 2021)]; Available online: https://covid.gov.cz/en/situations/register-vaccination/who-will-be-vaccinated-first.

Tarakji B., Umair A., Alakeel R., Ashok N., Azzeghaibi S., Darwish S., Mahmoud R., Elkhatat E. Hepatitis B vaccination and associated oral manifestations: A non-systematic review of literature and case reports. Ann. Med. Health Sci. Res. 2014;4:829. doi: 10.4103/2141-9248.144870. PubMed DOI PMC

McHugh M.L. Interrater reliability: The kappa statistic. Biochem. Med. 2012;22:276–282. doi: 10.11613/BM.2012.031. PubMed DOI PMC

OECD . Health at a Glance 2019. OECD; Paris, France: 2019.

Národní Pedagogický Institut České Republiky Odborní Pracovníci v Oblasti Zdravotnictví Kromě Všeobecných Sester bez Specializace. [(accessed on 8 March 2021)]; Available online: https://www.infoabsolvent.cz/Temata/ClanekAbsolventi/8-8-17.

Institute of Health Information and Statistics of the Czech Republic (UZIS) Health Yearbook of the Czech Republic 2017. [(accessed on 3 March 2021)];2018 Available online: https://www.uzis.cz/index-en.php?pg=record&id=8166.

Oliver S.E., Gargano J.W., Marin M., Wallace M., Curran K.G., Chamberland M., McClung N., Campos-Outcalt D., Morgan R.L., Mbaeyi S., et al. The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine—United States, December 2020. Morb. Mortal. Wkly. Rep. 2020;69:1922–1924. doi: 10.15585/mmwr.mm6950e2. PubMed DOI PMC

Ozdemir L., Pnarc E., Akay B.N., Akyol A. Effect of Methylprednisolone Injection Speed on the Perception of Intramuscular Injection Pain. Pain Manag. Nurs. 2013;14:3–10. doi: 10.1016/j.pmn.2010.03.002. PubMed DOI

Centers for Disease Control and Prevention (CDC) Interim Clinical Considerations for Use of COVID-19 Vaccines. [(accessed on 7 March 2021)]; Available online: https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fvaccines%2Fcovid-19%2Finfo-by-product%2Fpfizer%2Fclinical-considerations.html.

Training and Education Resources|COVID-19 Vaccination|CDC. [(accessed on 8 March 2021)]; Available online: https://www.cdc.gov/vaccines/covid-19/training-education-resources.html.

Pereira M.P., Flores P., Neto A.S. Neck and supraclavicular lymphadenopathy secondary to 9-valent human papillomavirus vaccination. BMJ Case Rep. 2019;12:e231582. doi: 10.1136/bcr-2019-231582. PubMed DOI PMC

Shirone N., Shinkai T., Yamane T., Uto F., Yoshimura H., Tamai H., Imai T., Inoue M., Kitano S., Kichikawa K., et al. Axillary lymph node accumulation on FDG-PET/CT after influenza vaccination. Ann. Nucl. Med. 2012;26:248–252. doi: 10.1007/s12149-011-0568-x. PubMed DOI

Studdiford J., Lamb K., Horvath K., Altshuler M., Stonehouse A. Development of Unilateral Cervical and Supraclavicular Lymphadenopathy After Human Papilloma Virus Vaccination. Pharmacotherapy. 2008;28:1194–1197. doi: 10.1592/phco.28.9.1194. PubMed DOI

Ministry of Interior—Czech Republic Information about Available Vaccines. Covid Portál. [(accessed on 3 March 2021)];2021 Available online: https://covid.gov.cz/en/situations/information-about-vaccine/information-about-available-vaccines.

Ministry of Interior—Czech Republic Specific Situations during Vaccination. Covid Portál. [(accessed on 3 March 2021)];2021 Available online: https://covid.gov.cz/en/situations/information-about-vaccine/specific-situations-during-vaccination.

ÚZIS-ČR . Stručný Přehled Činnosti Oboru Diabetologie a Endokrinologie 2017. Ústav Zdravotnických Informací a Statistiky ČR; Prague, Czech Republic: 2007.

Klugar M., Klugarová J., Pokorná A., Benešová K., Jarkovský J., Dolanová D., Mužík J., Líčeník R., Prázný M., Búřilová P., et al. Use of epidemiological analyses in Clinical Practice Guideline development focused on the diabetic patients treated with insulin. Int. J. Evid. Based. Healthc. 2019;17:S48–S52. doi: 10.1097/XEB.0000000000000188. PubMed DOI

Klugar M., Hunčovský M., Pokorná A., Dolanová D., Benešová K., Jarkovský J., Mužík J., Líčeník R., Nečas T., Búřilová P., et al. Epidemiological analyses for preparation of Clinical Practice Guidelines related to acute coronary syndromes in the Czech Republic. Int. J. Evid. Based. Healthc. 2019;17:S43–S47. doi: 10.1097/XEB.0000000000000185. PubMed DOI

ÚZIS-ČR . Zdravotnická ročenka ČR 2018. Ústav Zdravotnických Informací a Statistiky ČR; Prague, Czech Republic: 2018.

ÚZIS-ČR . Stručný Přehled Činnosti Oboru Pneumologie a Ftizeologie za Období 2007–2019. Ústav Zdravotnických Informací a Statistiky ČR; Prague, Czech Republic: 2007.

Bílek R., Horakova L., Gos R., Zamrazil V. Thyroid disease in the Czech Republic: The EUthyroid project and the evaluation of the General Health Insurance Company epidemiological data for the period of 2012–2015. Vnitř. Lék. 2017;63:548–554. PubMed

Nejnovějších 20 citací...

Zobrazit více v
Medvik | PubMed

Oral adverse events following COVID-19 and influenza vaccination in Australia

. 2023 Aug ; 19 (2) : 2253589. [epub] 20230921

Editorial: COVID-19 Vaccines Safety Tracking (CoVaST): Part I

. 2023 ; 11 () : 1154500. [epub] 20230224

Side Effects of COVID-19 Vaccines Primer Doses: Experience of Saudi Healthcare Workers Participating in CoVaST-SA

. 2022 Dec 13 ; 10 (12) : . [epub] 20221213

Self-reported side effects of the Oxford AstraZeneca COVID-19 vaccine among healthcare workers in Ethiopia, Africa: A cross-sectional study

. 2022 ; 10 () : 937794. [epub] 20220719

Oral Adverse Events Following COVID-19 Vaccination: Analysis of VAERS Reports

. 2022 ; 10 () : 952781. [epub] 20220711

Dental Care and Education Facing Highly Transmissible SARS-CoV-2 Variants: Prospective Biosafety Setting: Prospective, Single-Arm, Single-Center Study

. 2022 Jun 23 ; 19 (13) : . [epub] 20220623

Side Effects of COVID-19 Inactivated Virus vs. Adenoviral Vector Vaccines: Experience of Algerian Healthcare Workers

. 2022 ; 10 () : 896343. [epub] 20220516

Prevalence and Drivers of COVID-19 Vaccine Booster Hesitancy Among German University Students and Employees

. 2022 ; 10 () : 846861. [epub] 20220407

Headache onset after vaccination against SARS-CoV-2: a systematic literature review and meta-analysis

. 2022 Mar 31 ; 23 (1) : 41. [epub] 20220331

COVID-19 Vaccine Acceptance of Pregnant and Lactating Women (PLW) in Czechia: An Analytical Cross-Sectional Study

. 2021 Dec 19 ; 18 (24) : . [epub] 20211219

COVID-19 Vaccine Booster Hesitancy (VBH) of Healthcare Workers in Czechia: National Cross-Sectional Study

. 2021 Dec 06 ; 9 (12) : . [epub] 20211206

Self-Reported Adverse Events of COVID-19 Vaccines in Polish Healthcare Workers and Medical Students. Cross-Sectional Study and Pooled Analysis of CoVaST Project Results in Central Europe

. 2021 Nov 16 ; 10 (22) : . [epub] 20211116

Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18-30 Years Old): An Independent Post-Marketing Study

. 2021 Oct 15 ; 14 (10) : . [epub] 20211015

Universal Predictors of Dental Students' Attitudes towards COVID-19 Vaccination: Machine Learning-Based Approach

. 2021 Oct 10 ; 9 (10) : . [epub] 20211010

Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia

. 2021 Aug 29 ; 14 (9) : . [epub] 20210829

Predictors of Willingness to Receive COVID-19 Vaccine: Cross-Sectional Study of Palestinian Dental Students

. 2021 Aug 26 ; 9 (9) : . [epub] 20210826

Prevalence and Drivers of COVID-19 Vaccine Hesitancy among Czech University Students: National Cross-Sectional Study

. 2021 Aug 25 ; 9 (9) : . [epub] 20210825

Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers

. 2021 Aug 05 ; 10 (8) : . [epub] 20210805

COVID-19 Vaccines Safety Tracking (CoVaST): Protocol of a Multi-Center Prospective Cohort Study for Active Surveillance of COVID-19 Vaccines' Side Effects

. 2021 Jul 25 ; 18 (15) : . [epub] 20210725

Safety of ChAdOx1 nCoV-19 Vaccine: Independent Evidence from Two EU States

. 2021 Jun 18 ; 9 (6) : . [epub] 20210618

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...