Actions of calcitonin gene-related peptide on rat sensory ganglion neurones
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
2975794
Knihovny.cz E-zdroje
- MeSH
- evokované potenciály účinky léků MeSH
- inbrední kmeny potkanů MeSH
- kalcitonin farmakologie MeSH
- krysa rodu Rattus MeSH
- neurony aferentní účinky léků fyziologie MeSH
- neuropeptidy farmakologie MeSH
- peptid spojený s genem pro kalcitonin MeSH
- referenční hodnoty MeSH
- spinální ganglia účinky léků fyziologie MeSH
- techniky in vitro MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kalcitonin MeSH
- neuropeptidy MeSH
- peptid spojený s genem pro kalcitonin MeSH
The membrane actions of calcitonin gene-related peptide (CGRP) and the effect of CGRP on the Ca-dependent action potential of rat dorsal root ganglion (DRG) neurons have been studied by means of an intracellular recording technique in isolated DRG of 2-3-week-old rats in vitro. Bath application of CGRP (10(-8)-10(-6) M for 1-5 min) elicited a slow reversible hyperpolarization and this hyperpolarizing effect was still observed in the medium containing TTX and TEA. However, about half of the large cells, classified by duration of action potential, were depolarized by CGRP. These membrane effects of CGRP were associated with an increase in membrane input resistance (about 20%). In addition, CGRP increased the duration of Ca-dependent action potentials. Our results are consistent with the role of CGRP as an excitatory neurotransmitter or neuromodulator in DRG-spinal cord.
