Effects of dietary calcium on the development of salt hypertension in young and adult Dahl rats
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články
- MeSH
- dusík močoviny v krvi MeSH
- hypertenze etiologie MeSH
- krevní objem MeSH
- krysa rodu Rattus MeSH
- mutantní kmeny potkanů MeSH
- vápník dietní aplikace a dávkování MeSH
- vápník krev MeSH
- věkové faktory MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- vápník dietní MeSH
- vápník MeSH
The effect of dietary calcium on the development of salt hypertension was studied in young and adult Dahl rats. Age-dependent development of blood pressure was compared in salt-sensitive (DS) and salt-resistant (DR) Dahl rats that were fed either a low-calcium (0.15%) or a high-calcium (2.5%) diet. Systolic blood pressure was consistently higher in DS rats than in a comparable group of DR rats. In young DS rats the high-calcium diet transiently attenuated the development of hypertension, whereas in adult rats this diet potentiated the development of hypertension. In young DS rats total plasma calcium was increased by the high-calcium diet, but in adult rats it was significantly decreased. Our results suggest that the effects of dietary calcium supplementation on calcium metabolism and the development of salt hypertension in DS rats depend on the age at which calcium supplementation is started.
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Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension
Research on Experimental Hypertension in Prague (1966-2009)
