Evaluation of specific humoral immune responses in human filariasis
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
3311932
Knihovny.cz E-resources
- MeSH
- Antigens, Helminth immunology MeSH
- Brugia immunology MeSH
- Dirofilaria immitis immunology MeSH
- Elephantiasis, Filarial immunology MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Filarioidea immunology MeSH
- Filariasis immunology MeSH
- Counterimmunoelectrophoresis MeSH
- Immunoglobulin G analysis MeSH
- Immunoglobulin M analysis MeSH
- Humans MeSH
- Antibodies, Helminth analysis biosynthesis MeSH
- Wuchereria bancrofti immunology MeSH
- Wuchereria immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Names of Substances
- Antigens, Helminth MeSH
- Immunoglobulin G MeSH
- Immunoglobulin M MeSH
- Antibodies, Helminth MeSH
Using the antigens prepared from adult worms of B. malayi and D. immitis, a total of 37 malayan and 150 bancroftian serum samples were analysed for the presence of filarial specific antibodies by counterimmunoelectrophoresis and indirect enzyme linked immunosorbent assay. It was observed that microfilaraemic cases do show good specific humoral immune responses against homologous as well as heterologous antigen. Of the two antigens used, B. malayi adult antigen was found to be superior to D. immitis antigen in the detection of filarial antibodies.
