The first identification of the benzenediazonium ion formation from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) by microsomes of rat livers
Jazyk angličtina Země Irsko Médium print
Typ dokumentu časopisecké články
PubMed
3383183
DOI
10.1016/0304-3835(88)90091-2
PII: 0304-3835(88)90091-2
Knihovny.cz E-zdroje
- MeSH
- barvicí látky * MeSH
- benzoflavony MeSH
- biotransformace MeSH
- chromatografie na tenké vrstvě MeSH
- diazoniové sloučeniny analýza MeSH
- edaravon MeSH
- fenazon analogy a deriváty farmakologie MeSH
- inbrední kmeny potkanů MeSH
- jaterní mikrozomy metabolismus MeSH
- karcinogeny analýza MeSH
- krysa rodu Rattus MeSH
- naftoly metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 1-phenylazo-2-naphthol MeSH Prohlížeč
- barvicí látky * MeSH
- benzenediazonium MeSH Prohlížeč
- benzoflavony MeSH
- diazoniové sloučeniny MeSH
- edaravon MeSH
- fenazon MeSH
- karcinogeny MeSH
- naftoly MeSH
1-Phenylazo-2-hydroxynaphthalene (Sudan I) is converted by microsomal enzymes of rat livers in vitro to 5 products. Hepatic microsomes from 5,6-benzoflavone-treated rats are more effective for the metabolism of Sudan I than those from phenobarbital- or Sudan I alone-treated rats. Major products formed by microsomes are identified as the ring-hydroxyderivatives of benzene and naphthalene rings. The formation of the benzenediazonium ion evolved by oxidative splitting of the azo group of Sudan I by microsomal enzymes is also proved. The oxidative splitting of Sudan I by microsomal enzymes may be considered as the possible mechanism of the Sudan I activation to the ultimate carcinogen (benzenediazonium ion).
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