The first identification of the benzenediazonium ion formation from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) by microsomes of rat livers
Language English Country Ireland Media print
Document type Journal Article
PubMed
3383183
DOI
10.1016/0304-3835(88)90091-2
PII: 0304-3835(88)90091-2
Knihovny.cz E-resources
- MeSH
- Coloring Agents * MeSH
- Benzoflavones MeSH
- Biotransformation MeSH
- Chromatography, Thin Layer MeSH
- Diazonium Compounds analysis MeSH
- Edaravone MeSH
- Antipyrine analogs & derivatives pharmacology MeSH
- Rats, Inbred Strains MeSH
- Microsomes, Liver metabolism MeSH
- Carcinogens analysis MeSH
- Rats MeSH
- Naphthols metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- 1-phenylazo-2-naphthol MeSH Browser
- Coloring Agents * MeSH
- benzenediazonium MeSH Browser
- Benzoflavones MeSH
- Diazonium Compounds MeSH
- Edaravone MeSH
- Antipyrine MeSH
- Carcinogens MeSH
- Naphthols MeSH
1-Phenylazo-2-hydroxynaphthalene (Sudan I) is converted by microsomal enzymes of rat livers in vitro to 5 products. Hepatic microsomes from 5,6-benzoflavone-treated rats are more effective for the metabolism of Sudan I than those from phenobarbital- or Sudan I alone-treated rats. Major products formed by microsomes are identified as the ring-hydroxyderivatives of benzene and naphthalene rings. The formation of the benzenediazonium ion evolved by oxidative splitting of the azo group of Sudan I by microsomal enzymes is also proved. The oxidative splitting of Sudan I by microsomal enzymes may be considered as the possible mechanism of the Sudan I activation to the ultimate carcinogen (benzenediazonium ion).
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