Caesium fluoride-induced changes in the c.d. spectra of synthetic DNA fragments
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
PubMed
2059585
DOI
10.1016/0141-8130(91)90003-d
PII: 0141-8130(91)90003-D
Knihovny.cz E-zdroje
- MeSH
- adeninnukleotidy chemie MeSH
- cesium chemie MeSH
- cirkulární dichroismus MeSH
- DNA chemie MeSH
- fluoridy * MeSH
- isomerie MeSH
- konformace nukleové kyseliny MeSH
- makromolekulární látky MeSH
- molekulární modely MeSH
- molekulární sekvence - údaje MeSH
- oligonukleotidy chemie MeSH
- polynukleotidy chemie MeSH
- sekvence nukleotidů MeSH
- spektrofotometrie ultrafialová MeSH
- thiminnukleotidy chemie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adeninnukleotidy MeSH
- cesium fluoride MeSH Prohlížeč
- cesium MeSH
- DNA MeSH
- fluoridy * MeSH
- makromolekulární látky MeSH
- oligonukleotidy MeSH
- polynukleotidy MeSH
- thiminnukleotidy MeSH
Ten DNA fragments containing self-complementary alternating sequences of adenine and thymine differing in length and the starting nucleotide were studied by c.d. spectroscopy. It was found that d(TATATATA) but not d(ATATATAT), d(TATATA), d(CTATATAG) or (dT-dA)20 isomerized into the unusual X-DNA double helix at molar concentrations of CsF in solution. But in contrast to poly(dA-dT), the octamer (dT-dA)4, isomerized very slowly, at relatively low CsF concentrations and the isomerization was strongly dependent on the octamer concentration. A model is proposed to account for the observed properties of the B-to-X isomerization on the oligomer level.
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