Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type one diabetes responsive TCR[Formula: see text] sequences .

Biological Faculty Moscow State University Moscow Russia

Center for Data Intensive Biomedicine and Biotechnology Skolkovo Institute of Science and Technology Moscow Russia

Central European Institute of Technology Brno Czech republic

Department of Genomics of Adaptive Immunity Shemyakin Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow Russia

Laboratoire de Physique Statistique CNRS Sorbonne University Paris Diderot University École Normale Supérieure Paris France

Laboratoire de Physique Theorique CNRS Sorbonne University École Normale Supérieure Paris France

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