The dsRNA of Trichomonas vaginalis is associated with virus-like particles and does not correlate with metronidazole resistance
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
3499366
DOI
10.1007/bf02877224
Knihovny.cz E-zdroje
- MeSH
- DNA virů izolace a purifikace MeSH
- dvouvláknová RNA izolace a purifikace MeSH
- léková rezistence MeSH
- metronidazol farmakologie MeSH
- Trichomonas vaginalis analýza účinky léků ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- DNA virů MeSH
- dvouvláknová RNA MeSH
- metronidazol MeSH
Twelve metronidazole-resistant and twelve metronidazole-susceptible strains of Trichomonas vaginalis were tested for the presence of dsRNA. Three resistant and five susceptible strains were found to contain dsRNA which indicated that metronidazole resistance does not correlate with the absence of dsRNA. Electron microscopy showed the homogenates of all dsRNA-positive strains to contain virus-like particles 32-38 nm in diameter, while no such particles were found in the dsRNA-negative strains. A mutual relationship between the dsRNA and virus-like particles seems to exist.
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Concordance between genetic relatedness and phenotypic similarities of Trichomonas vaginalis strains
Multiple populations of double-stranded RNA in two virus-harbouring strains of Trichomonas vaginalis