Aminoglycoside resistance patterns in clinical isolates of Enterobacteriaceae from Czechoslovakia
Language English Country Great Britain, England Media print
Document type Comparative Study, Journal Article
PubMed
3680076
DOI
10.1093/jac/20.3.383
Knihovny.cz E-resources
- MeSH
- Acetyltransferases metabolism MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Drug Resistance, Microbial MeSH
- Bacteriuria microbiology MeSH
- Enterobacteriaceae drug effects enzymology MeSH
- Enterobacteriaceae Infections microbiology MeSH
- Gentamicins pharmacology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Geographicals
- Czechoslovakia MeSH
- Names of Substances
- Acetyltransferases MeSH
- Anti-Bacterial Agents MeSH
- Gentamicins MeSH
Multi-resistant Enterobacteriaceae isolated mainly from urine specimens from patients at the Department of Urology, Kramáre Hospital, Bratislava, were characterized for resistance phenotype. Seventeen gentamicin-resistant isolates were further studied for the presence of aminoglycoside-modifying enzymes. Five enzymes were detected: AAC(2'), AAC(3)-II, AAC non-characterized, ANT(2") and APH(3')-I. The substrate range of these enzymes was found to correlate with the resistance phenotype in most isolates. In our collection the AAC(3)-II enzyme that inactivates gentamicin, sisomicin, tobramycin and netilmicin was predominant. Predominance of this type of modifying enzyme has been observed also in resistant Gram-negative strains in Belgium, The Netherlands and Chile, in contrast to the United States, Federal Republic of Germany, Switzerland, Greece and Turkey, where ANT(2") has been the most common enzyme.
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