Aminoglycoside resistance patterns in clinical isolates of Enterobacteriaceae from Czechoslovakia
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
3680076
DOI
10.1093/jac/20.3.383
Knihovny.cz E-zdroje
- MeSH
- acetyltransferasy metabolismus MeSH
- antibakteriální látky farmakologie MeSH
- antibiotická rezistence MeSH
- bakteriurie mikrobiologie MeSH
- Enterobacteriaceae účinky léků enzymologie MeSH
- enterobakteriální infekce mikrobiologie MeSH
- gentamiciny farmakologie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Geografické názvy
- Československo MeSH
- Názvy látek
- acetyltransferasy MeSH
- antibakteriální látky MeSH
- gentamiciny MeSH
Multi-resistant Enterobacteriaceae isolated mainly from urine specimens from patients at the Department of Urology, Kramáre Hospital, Bratislava, were characterized for resistance phenotype. Seventeen gentamicin-resistant isolates were further studied for the presence of aminoglycoside-modifying enzymes. Five enzymes were detected: AAC(2'), AAC(3)-II, AAC non-characterized, ANT(2") and APH(3')-I. The substrate range of these enzymes was found to correlate with the resistance phenotype in most isolates. In our collection the AAC(3)-II enzyme that inactivates gentamicin, sisomicin, tobramycin and netilmicin was predominant. Predominance of this type of modifying enzyme has been observed also in resistant Gram-negative strains in Belgium, The Netherlands and Chile, in contrast to the United States, Federal Republic of Germany, Switzerland, Greece and Turkey, where ANT(2") has been the most common enzyme.
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