Effects of tertiary amine local anaesthetics on the phase behaviour of the dipalmitoylphosphatidylcholine model membrane. Electron spin resonance tetrametylpiperidinyloxyl partition study
Physiologia Bohemoslovaca.
1984 ;
33 (6) :
489-94.
Language English Country Czech Republic Media print
Document type Journal Article
Persistent link
https://www.medvik.cz/link/pmid06099578
PubMed
6099578
Knihovny.cz E-resources
- MeSH
- Anesthetics, Local pharmacology MeSH
- Cyclic N-Oxides MeSH
- Electron Spin Resonance Spectroscopy MeSH
- Membranes, Artificial * MeSH
- Pulmonary Surfactants MeSH
- Spin Labels MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anesthetics, Local MeSH
- Cyclic N-Oxides MeSH
- Membranes, Artificial * MeSH
- Pulmonary Surfactants MeSH
- Spin Labels MeSH
- tempol MeSH Browser
Using the electron spin resonance technique of the spin probe (TEMPO) is shown that local anaesthetics lidocaine, tetracaine, dibucaine, heptacaine and carbizocaine decrease the gel--liquid crystal phase transition temperature and increase the width of the phase transition of the dipalmitoylphosphatidylcholine (DPPC) model membrane. These effects roughly correlate with the efficiencies of the anesthetics to block action potential propagation in the nerves.
TheScientificWorldJournal.
2013 ;
2013 () :
274570.
[epub] 20131029
