Location of the gene responsible for Rous sarcoma regression in the B-F region of the B complex (MHC) of the chicken
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
6271604
Knihovny.cz E-resources
- MeSH
- Major Histocompatibility Complex * MeSH
- Chickens genetics MeSH
- Chromosome Mapping * MeSH
- Sarcoma, Avian genetics immunology MeSH
- Neoplasm Regression, Spontaneous * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
We studied the fate of tumours induced by PR-RSV-C and B77-C in inbred chicken lines CB, CC and CB.R1. Rous sarcomas regressed in the CB and CB.R1 lines which are identical in the B-F region of the B complex. In contrast, progressive tumour growth was observed in the CC line which differed in the B-F region from the CB and CB.R1 lines and was identical in the B-G region with the CB.R1 line. These results suggest that the gene responsible for Rous sarcoma regression is located in the B-F region of the B complex.
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