Phosphorylation of cerebral cortex proteins during spreading cortical depression
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
6452634
Knihovny.cz E-resources
- MeSH
- Cell Membrane metabolism MeSH
- Cell Nucleus metabolism MeSH
- Cytosol metabolism MeSH
- Phosphorus metabolism MeSH
- Phosphorylation MeSH
- Rats MeSH
- Microsomes metabolism MeSH
- Mitochondria metabolism MeSH
- Cerebral Cortex cytology metabolism MeSH
- Nerve Tissue Proteins metabolism MeSH
- Cortical Spreading Depression * MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Phosphorus MeSH
- Nerve Tissue Proteins MeSH
Spreading cortical depression induced by the topical application of 25 % KC1 onto on hemisphere of the rat brain produced an increase in 32P radioactivity in the proteins of the microsomal [+39 %] and membrane [+21 %] fraction of the affected hemicortex compared with the intact contralateral hemicortex; conversely, radioactivity in the cytosol fraction fell by 19 %, while in the mitochondrial fraction it remained the same. The results are evaluated from the aspects of a possible difference in the response of cAMP-dependent and cAMP-independent protein phosphorylation to the depolarization of cortical cells in vivo.
