Correlations between adrenal weight and heart weight in rats with a cardiac overload
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
6458048
Knihovny.cz E-resources
- MeSH
- Aorta, Abdominal MeSH
- Digitoxin pharmacology MeSH
- Thyroid Hormones pharmacology MeSH
- Hyperthyroidism complications MeSH
- Rats, Inbred Strains MeSH
- Cardiomegaly etiology pathology MeSH
- Rats MeSH
- Ligation MeSH
- Myocardium pathology MeSH
- Adrenal Glands pathology MeSH
- Organ Size * drug effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Digitoxin MeSH
- Thyroid Hormones MeSH
- thyroidin MeSH Browser
A significant positive correlation between heart weight and adrenal weight was found in rats with myocardial hypertrophy induced by experimental hyperthyroidism or ligation of the abdominal aorta. The simultaneous administration of digitoxin partly inhibited myocardial hypertrophy after ligation of the abdominal aorta, but not after experimental hyperthyroidism. Digitoxin also inhibited adrenal hypertrophy after ligature of the abdominal aorta but, again, not after experimental hyperthyroidism. The possible existence of an endogenous cardiotropic hormone participating in the development of cardiac hypertrophy from overloading is discussed.
The endogenous digitalis-like factor
