Quantitative predictivity of carcinogenicity for four short-term parameters, evaluated in rat liver: alkaline DNA fragmentation, autoradiographic repair, DNA adducts, preneoplastic nodules
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
6724053
Knihovny.cz E-resources
- MeSH
- Amines toxicity MeSH
- Azo Compounds toxicity MeSH
- DNA metabolism MeSH
- Hydrocarbons, Halogenated toxicity MeSH
- Hydrazines toxicity MeSH
- Liver drug effects metabolism MeSH
- Carcinogens metabolism toxicity MeSH
- Rats MeSH
- Mycotoxins toxicity MeSH
- Liver Neoplasms pathology MeSH
- Nitrosamines toxicity MeSH
- DNA Repair * MeSH
- Polycyclic Compounds toxicity MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Amines MeSH
- Azo Compounds MeSH
- DNA MeSH
- Hydrocarbons, Halogenated MeSH
- Hydrazines MeSH
- Carcinogens MeSH
- Mycotoxins MeSH
- Nitrosamines MeSH
- Polycyclic Compounds MeSH
The possibility of the study of a quantitative correlation between short-term tests and carcinogenicity, instead of a qualitative one, is discussed. Four tests related to the target organ, rat liver, were considered: alkaline DNA fragmentation, DNA repair, DNA adducts and the formation of preneoplastic nodules. All the four tests showed a similar level of correlation with carcinogenic potency (r approximately equal to 0.4). With this level of correlation, the dispersion of the data appeared too large to offer a meaningful degree of quantitative predictivity of carcinogenicity, in reference to a single test. It appeared however, that the use of a battery of two or three independent short-term tests, with the above level of simple correlation, could generate a multiple correlation high enough to be potentially useful for some degree of quantitative predictivity of carcinogenic potency.
