Chronic sympathetic nervous system overactivity has been implicated in the pathogenesis of both hypertension and hypercholesterolemia. We conducted a controlled trial to determine the effect of a relaxation technique on blood pressure and serum cholesterol in drug free subjects with normal and slightly elevated values. Over the follow-up period, highly significant reductions in blood pressure and serum cholesterol levels were noted in relaxation group subjects while control group subjects showed no significant changes. These results suggest that relaxation therapy may contribute to the management of individuals with mild hypertension and/or mild hypercholesterolemia.