Mutation modifying the serine pathway in methylotrophic bacteria
Language English Country United States Media print
Document type Journal Article
PubMed
6792008
DOI
10.1007/bf02927420
Knihovny.cz E-resources
- MeSH
- Bacillus genetics metabolism MeSH
- Glycine pharmacology MeSH
- Glycine Hydroxymethyltransferase metabolism MeSH
- Isocitrate Lyase metabolism MeSH
- Carbohydrate Dehydrogenases metabolism MeSH
- Glyceric Acids metabolism MeSH
- Methanol metabolism MeSH
- Micrococcus genetics metabolism MeSH
- Mutation * MeSH
- Serine metabolism MeSH
- Transaminases metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Glycerate dehydrogenase MeSH Browser
- Glycine MeSH
- glycine-oxaloacetate aminotransferase MeSH Browser
- Glycine Hydroxymethyltransferase MeSH
- Isocitrate Lyase MeSH
- Carbohydrate Dehydrogenases MeSH
- Glyceric Acids MeSH
- Methanol MeSH
- Serine MeSH
- Transaminases MeSH
Methylotrophic bacteria, Gram-positive, with the serine pathway, were shown to have their growth inhibited by 0.5% glycine. The effects of this amino acid on individual enzyme activities were studied in wild and mutant strains of Micrococcus varians and Bacillus licheniformis. The enzymes studied were glycerate dehydrogenase (EC 1.1.1.29), isocitrate lyase (EC 4.1.3.1), serine hydroxymethyltransferase (EC 2.1.2.1) and glycine--oxaloacetate aminotransferase (EC 2.6.1.35). The last-named enzyme was found to be inhibited, the kinetic constants having been determined for two strain types.
