Mutagenic effect of n-methyl-N-nitrosourea on Mycobacterium phlei
Language English Country United States Media print
Document type Journal Article
PubMed
7203289
DOI
10.1007/bf02927225
Knihovny.cz E-resources
- MeSH
- Amino Acids metabolism MeSH
- Drug Resistance, Microbial MeSH
- Pigments, Biological biosynthesis MeSH
- Isoniazid pharmacology MeSH
- Methylnitrosourea pharmacology MeSH
- Mutation * MeSH
- Mycobacterium phlei genetics physiology MeSH
- Mycobacterium genetics MeSH
- Nitrosoguanidines pharmacology MeSH
- Nitrosourea Compounds pharmacology MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Amino Acids MeSH
- Pigments, Biological MeSH
- Isoniazid MeSH
- Methylnitrosourea MeSH
- Nitrosoguanidines MeSH
- Nitrosourea Compounds MeSH
N-Methyl-N-nitrosourea was used to induce auxotrophic, scotochromogenic and isonicotinic acid hydrazide resistant mutants in Mycobacterium phlei and its effect was compared with that of nitrosoguanidine. Seventeen auxotrophic mutants requiring amino acids or vitamins and 52 scotochromogenic mutants with orange colonies were induced. The frequency of isonicotinic acid hydrazide-resistant mutants increased by two orders of magnitude.
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