Partial trisomy (including T-t gene complex) of the chromosome 17 of the mouse. The effect on male fertility and the transmission to progeny
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
7262351
Knihovny.cz E-zdroje
- MeSH
- fertilita * MeSH
- geny * MeSH
- heterozygot MeSH
- myši MeSH
- trizomie * MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
The animals with partial trisomy of chromosome 17, Ts(17A1-17B) 43H, were recovered among progeny of females heterozygous for T(16;17)43H "male-sterile" translocation. The trisomics as well as Rb7Bnr/T43H hybrids of both sexes were fertile, although the male fertility was significantly reduced in comparison with T43H/T43H homozygotes and males without chromosomal rearrangements. Ts43H trisomy acts as a semilethal aneuploidy since a significant deficiency of Ts43H animals was observed in progeny of Ts43H parent, while the expected proportion of trisomic embryos was found up to the 18th day of embryonic development.
Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes
Segmental trisomy of mouse chromosome 17: introducing an alternative model of Down's syndrome
