Seizures induced by homocysteine in rats during ontogenesis
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Behavior, Animal drug effects MeSH
- Electroencephalography MeSH
- Excitatory Amino Acids pharmacology MeSH
- Receptors, Glutamate drug effects MeSH
- Homocysteine pharmacology MeSH
- Rats MeSH
- Kainic Acid pharmacology MeSH
- Brain drug effects growth & development MeSH
- N-Methylaspartate pharmacology MeSH
- Animals, Newborn MeSH
- Rats, Wistar MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures etiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Excitatory Amino Acids MeSH
- Receptors, Glutamate MeSH
- Homocysteine MeSH
- Kainic Acid MeSH
- N-Methylaspartate MeSH
We studied the convulsant action of homocysteine in 211 immature and adult Wistar albino rats. Homocysteine elicited minimal, predominantly clonic, and major generalized tonic-clonic seizures at six different developmental stages, from 7 days to adulthood. Nevertheless, some age-dependent differences in the seizure pattern were apparent. Minimal seizures in immature rats lasted < or = 20 min, thus representing an epileptic status, whereas in adult animals these seizures were much shorter, lasting only < or = 40 s. In addition, flexion seizures were observed in 7- and 12-day-old rats, only rarely in 15- and 18-day-old animals, and never in the 25-day-old and adult rats. ECoG recordings demonstrated a nearly isoelectric pattern during homocysteine-induced seizures in 7- and 12-day-old rat pups. In older rats, spikes or sharp waves were recorded, but precise electroclinical correlations were poor. The greater sensitivity of younger animals to kainic acid (KA) and N-methyl-D-aspartate (NMDA), as reported previously, was not evident in the case of homocysteine-induced seizures. This observation, together with a different behavioral pattern, suggests that homocysteine cannot be considered a simple agonist of the kainate or NMDA type of excitatory amino acid receptors. The exact mechanism of the convulsant action of homocysteine, both during development and in adulthood, remains to be clarified.
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
