In vitro susceptibility to 9 antifungal agents of 14 strains of Zygomycetes isolated from clinical specimens

. 1994 Dec ; 128 (3) : 135-7.

Jazyk angličtina Země Nizozemsko Médium print

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid07739727

Fourteen clinical isolates of Zygomycetes were tested for their in vitro susceptibility to nine antifungal agents. Susceptibility assessment was performed using a microtiter broth dilution method. Synthetic broth with YNB and glucose was used for 5-fluorocytosine and BHI broth for all the other antimycotics. Amphotericin B exhibited the strongest activity against all isolates tested. MIC values of other two polyenes--nystatin and pimaricin--ranged within the susceptibility limits, with a little pronounced higher activity of pimaricin. The isolates of the genus Absidia and Syncephalastrum were well sensitive to all antimycotics with the exception of 5-fluorocytosine and naftifine. A very weak or zero growth inhibitory effect against all members of the genera Mucor and Rhizopus was found in azoles, 5-fluorocytosine and naftifine.

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