In vitro susceptibility to 9 antifungal agents of 14 strains of Zygomycetes isolated from clinical specimens
Language English Country Netherlands Media print
Document type Journal Article
PubMed
7739727
DOI
10.1007/bf01138473
Knihovny.cz E-resources
- MeSH
- Allylamine analogs & derivatives pharmacology MeSH
- Antifungal Agents pharmacology MeSH
- Azoles pharmacology MeSH
- Flucytosine pharmacology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Mucor drug effects MeSH
- Mucorales drug effects MeSH
- Rhizopus drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Allylamine MeSH
- Antifungal Agents MeSH
- Azoles MeSH
- Flucytosine MeSH
- naftifine MeSH Browser
Fourteen clinical isolates of Zygomycetes were tested for their in vitro susceptibility to nine antifungal agents. Susceptibility assessment was performed using a microtiter broth dilution method. Synthetic broth with YNB and glucose was used for 5-fluorocytosine and BHI broth for all the other antimycotics. Amphotericin B exhibited the strongest activity against all isolates tested. MIC values of other two polyenes--nystatin and pimaricin--ranged within the susceptibility limits, with a little pronounced higher activity of pimaricin. The isolates of the genus Absidia and Syncephalastrum were well sensitive to all antimycotics with the exception of 5-fluorocytosine and naftifine. A very weak or zero growth inhibitory effect against all members of the genera Mucor and Rhizopus was found in azoles, 5-fluorocytosine and naftifine.
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