Immunosuppression and feeding success of Ixodes ricinus nymphs on BALB/c mice
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- imunologická tolerance MeSH
- infestace klíšťaty imunologie patologie MeSH
- interakce hostitele a parazita MeSH
- klíšťata imunologie fyziologie MeSH
- kůže parazitologie patologie MeSH
- lymfocyty imunologie MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- nymfa MeSH
- recidiva MeSH
- slezina cytologie imunologie MeSH
- stravovací zvyklosti MeSH
- tvorba protilátek MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The effect of repeated infestations of Ixodes ricinus (L.) nymphs on BALB/c mice was studied. Four successive infectations resulted in an increase of tick feeding success. Tick yield and mean engorged weight increased and the length of the feeding period was reduced significantly (P < 0.05-0.01). The increase of specific anti-tick antibodies was not significant (P > 0.05). The blastogenic response of spleen lymphocytes to T-cell mitogens (Con A and PHA-P) was unimpaired or slightly enhanced, whereas the response to B-cell activators (LPS and PWM) was suppressed, as was the total antibody generation in vitro. The numbers of mast cells in murine skin at the tick attachment sites slightly decreased during the third infestation. The suppression of B-cell competence and of antibody generation, together with decrease of skin mast cell numbers in tick attachment sits, are considered to be responsible for enhancement of tick feeding success.
Citace poskytuje Crossref.org
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