Developmental changes of ketamine action against epileptic afterdischarges induced by hippocampal stimulation in rats
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
PubMed
7805275
DOI
10.1016/0165-3806(94)90072-8
PII: 0165-3806(94)90072-8
Knihovny.cz E-zdroje
- MeSH
- antikonvulziva farmakologie MeSH
- chování zvířat účinky léků MeSH
- elektrická stimulace MeSH
- elektroencefalografie účinky léků MeSH
- elektrofyziologie MeSH
- epilepsie farmakoterapie patofyziologie MeSH
- hipokampus účinky léků růst a vývoj patofyziologie MeSH
- ketamin farmakologie MeSH
- krysa rodu Rattus MeSH
- modely nemocí na zvířatech MeSH
- potkani Wistar MeSH
- věkové faktory MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antikonvulziva MeSH
- ketamin MeSH
Action of ketamine (5-40 mg/kg) was tested against electrically induced hippocampal afterdischarges (four stimulations in one session; 8 Hz, 15 s) in rats 7, 12, 18, 25 and 90 days old. In control sessions, there was either stable afterdischarge (AD) duration and wet dog shakes (WDS) number or there was an increase in ADs' duration with repeated stimulations. Ketamine had dose-dependent and age-dependent effects. In 7-18-day-old rats, ketamine suppressed better WDS number than AD duration, with nearly absent action on AD duration in 18-day-old animals. Ketamine was equipotent for both phenomena in 25-day-old rats and, in contrast, it decreased more AD duration than WDS number in 90-day-old rats. The data suggest a differentiation induced by ketamine in the expression of motor and electrographic phenomena of the experimental seizures.
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